当科の紹介

血液・腫瘍グループ

所属メンバー

・真部 淳 (教授)(昭和60年卒)
(日本小児科学会専門医/指導医、日本血液学会専門医/指導医、日本小児血液・がん学会評議員/専門医/指導医、日本小児がん研究グループJCCG代議員)

メッセージ:「北大に赴任して2年たちました。キムリアなど新しい治療が始まり、がんゲノム診療とgermline遺伝子多型の検索が進み、新しい治療をめざして基礎研究も始まりました。また固形腫瘍を中心に、北大内の他科との連携、北海道全体の他施設との連携が進んでいます。長期フォローアップも体系的に行われ、AYA世代のがんへの取り組みも軌道に乗っています。今後、全国を引っ張ってゆくような若手の育成が急務です。血液・腫瘍グループへのご支援をお願いします。」

・長 祐子 (診療講師)(平成2年卒)
(日本小児科学会専門医/指導医、日本血液学会専門医/指導医、日本小児血液・がん学会評議員/専門医/指導医、日本がん治療認定医機構がん治療認定医、日本小児がん研究グループJCCG神経芽腫委員会委員/横紋筋肉腫委員会委員/支持療法委員会委員)

メッセージ:「北海道がんセンターとも連携しながら、肉腫をはじめとした小児固形腫瘍の診療に力を注いでいます。また子どもたちが可能な限り苦痛の少ない闘病生活をおくることができるよう、多職種で小児サポートチーム(Team for Kid’s Comfort, 通称KiC)を結成し、北大病院緩和ケアチームの中の小児部門として定期の勉強会によるスタッフのレベルアップや小児科領域への支持・緩和医療の普及を目指した活動を始めています。医師として薬物療法の習熟はもちろん、この領域は研究計画における適用尺度や数値化が難しいため、そういった勉強の機会にも触れたいと最近感じています。」

・平林 真介 (助教)(平成16年卒)
(日本小児科学会専門医/指導医、日本血液学会専門医/指導医/評議員、日本小児血液・がん学会専門医/評議員、造血細胞移植認定医、日本小児がん研究グループJCCG JMML委員会委員)

メッセージ:「これまでは骨髄異形成症候群や急性リンパ性白血病の臨床研究に携わってきました。最先端医療の導入に後れを取ることなく、日々の医療に還元できるように努力して参りたいです。現在、多くの若手医師が血液腫瘍を志してくれておりますが、研究には際限がないと思いますので切磋琢磨していきましょう!個人的には、北海道の自然の中で肉体改造を模索中です。」

・杉山 未奈子 (がん遺伝子診療部)(平成17年卒)
(日本小児科学会専門医/指導医、日本血液学会専門医、造血細胞移植認定医、日本がん治療認定医機構がん治療認定医)

メッセージ:「国立がん研究センター中央病院に半年間お世話になり、4月に戻って来ました。小児がんの中でも難治な希少がんに向き合う子どもたちとの多くの出会いがありました。がん遺伝子パネル検査を含む、道内の固形腫瘍の診療体制の整備に取り組みます。小児がんの子どもたちが北海道で安心して治療を受けられる環境を、次の世代へつないでいけたらと思います。」

・寺下 友佳代 (医員)(平成17年卒)
(日本小児科学会専門医/指導医、日本血液学会専門医)

メッセージ:「日々の診療の中で子ども達に教わることが沢山あります。いま成長している子ども達のため、将来のある若者たちのため、他科・多職種のスタッフとともに長期フォローアップと移行期医療の体制の整備に力を注ぎます。」

・澤井 彩織 (大学院生)(平成27年卒)
メッセージ:「4月に医学院へ入学しました。主に病棟での診療を通して、血液・腫瘍疾患について学んでいます。当院は小児がん拠点病院であり、様々な症例が集まります。かつ、陽子線治療やCAR-T細胞療法等、北海道では当院しかできない治療も経験することができ、非常に恵まれた環境で勉強させて頂いていると実感しております。北海道の小児がん診療に少しでも貢献出来ますよう、精進致します。」

診療実績

(2020年1月~2020年12月)
外来患者数 1543人/年(延べ)
入院患者数 142人/年(延べ)

診療内容

北海道における小児がん拠点病院を支える小児科 血液・腫瘍グループとして、道内の小児血液・腫瘍疾患を診療している他大学や病院と密に連携しています。

主に小児血液疾患(再生不良性貧血などの造血障害、白血病などの造血器腫瘍、血友病などの先天性凝固異常 他)の診断・治療、および固形腫瘍(脳腫瘍、神経芽細胞腫、横紋筋肉腫などの骨軟部腫瘍、ウイルムス腫瘍、肝芽腫 他)の診断・治療を行っており、道内の多くの、そして様々な血液疾患・悪性腫瘍の子どもたちが集まってきますが、このような子どもたちは最初から深刻な病を疑って大学病院に来るわけではありません。大人に比べて乏しい訴えから鑑別疾患を挙げ、治療に結びつけるまでには時に困難が伴います。活気不良や発熱から、また健診や予防接種の場面で病気を見つけ出し紹介してくださる、そして治療後の経過を共に診てくださる関連病院との連携が不可欠です。

われわれは、個々の臨床家としての経験の蓄積やスキルの向上は無論のこと、定期的に集中カンファレンス、抄読会などの勉強会を行い、グループ全体のレベルアップにも努めています。また小児外科、脳神経外科、病理診断科、放射線治療科と定期的にTumor board(腫瘍症例検討会)を開催しています。さらに呼吸器外科、耳鼻咽喉科、整形外科、婦人科、泌尿器科、児童精神科などあらゆる診療科とタッグを組んで子どもたちにとっての最善の医療を追求できるのは大学病院の強みです。

時間軸では、内分泌グループ、循環器グループの先生方と協同し、長期フォローアップ(晩期障害への対応)システムの強化を進めているほか、血液内科、腫瘍内科など成人の診療科とも協力し思春期から成人へと成長していく小児~青年期(AYA世代)の患者・家族の診療・フォローアップ、すなわち「移行期医療」「成人移行支援」にも取り組んでいます。

診療においては化学療法のほか積極的に造血幹細胞移植(自家/血縁/非血縁 骨髄移植/末梢血幹細胞移植/臍帯血移植)を行っており、大学病院小児科としては日本でも有数の移植症例数であり2021年4月現在で総計319(延べ)の造血幹細胞移植をおこなってきました。近年は、骨髄非破壊的移植、複数回移植、およびHLA半合致移植など、従来の移植よりも合併症や困難を伴う移植症例が増加しています。

北海道内の地域中核病院はもちろん道外からも広く患者を受け入れています。2016年4月より小児がんに対する陽子線治療が保険適応となり、陽子線治療のために当院を受診される方も増えています。2019年には最先端のがん免疫療法として注目されているCAR-T療法も小児科として導入しました。さらに難治性固形腫瘍の代表である神経芽腫に対する放射線療法として131I-MIBG内照射診療について現在、核医学講座と連携して準備を進めています。そして、がんゲノム医療が広く知られるようになってきましたが、当グループでは稀少あるいは難治固形腫瘍を抱えた小児症例に対してオンコパネルを積極的に適用し、新たな治療の模索も行なっています。

このような化学療法や造血幹細胞移植をより安全に行うためには、子どもの全身を診る力が必要で、広大な北海道の各地域の小児医療を懸命に守ってきた研修医時代の経験や学びが生きる領域の一つです。また多科連携による集学的治療、多職種連携によるチーム医療の醍醐味を感じることのできる領域でもあります。

研究

小児血液疾患および小児固形腫瘍疾患に対し、化学療法や造血幹細胞移植などを用いて治療を行っています。診療を進めていく中で、病気そのものの病態を解析し病気の原因を明らかにすること、また可能な限り安全で患者さんやそのご家族に負担の少ない方法を模索し苦痛や合併症を少なくすることが我々の願いです。そのために現在、以下のような研究を進めています。

1. 小児急性リンパ性白血病の臨床研究の推進(JCCG)
2. 小児骨髄異形成症候群の病態と治療(小児MDS治療研究会)
3. 小児とAYA世代のがん患者の妊孕性保存の推進(北大腫瘍センター)
4. 造血幹細胞移植後の肝中心静脈閉塞症などの合併症の病態解析
5. PID移植症例におけるATG使用例のウイルス再活性化を含む移植合併症の解析(日本造血細胞移植学会 移植登録一元管理プログラム TRUMPを介した全国調査)
6. 化学療法および移植後回復期の自己免疫疾患の解析
7. PT-CYを用いた小児造血細胞移植の臨床的解析
8. 札幌市神経芽腫マススクリーニングの有用性に関する解析
9. 小児がん患者における処置・治療関連疼痛の緩和に関する臨床的解析

など

業績

(直近5年間)

論文・著書など(欧文のみ)
1) Kato M, Ishida H, Koh K, Inagaki J, Kato K, Goto H, Kaneko T, Cho Y, Hashii Y, Kurosawa H, Takita J, Hamamoto K, Inoue M, Sawada A, Suzuki R, Kato K Comparison of chemotherapeutic agents as a myeloablative conditioning with total body irradiation for pediatric acute lymphoblastic leukemia: A study from the pediatric ALL working group of the Japan Society for Hematopoietic Cell Transplantation. Pediatr Blood Cancer. 2015; 62: 1844-50.
2) Hayasaka I, Cho K, Morioka K, Kaneshi Y, Akimoto T, Furuse Y, Moriichi A, Iguchi A, Cho Y, Minakami H, Ariga T. Exchange transfusion in patients with Down syndrome and severe transient leukemia. Pediatr Int. 2015; 57: 620-5.
3) Iguchi A, Terashita Y, Sugiyama M, Ohshima J, Sato TZ, Cho Y, Kobayashi R, Ariga T. Graft-versus-host disease (GVHD) prophylaxis by using methotrexate decreases pre-engraftment syndrome and severe acute GVHD, and accelerates engraftment after cord blood transplantation. Pediatr Transplant. 2016; 20: 114-9.
4) Ishi Y, Yamaguchi S, Iguchi A, Cho Y, Ohshima J, Hatanaka KC, Takakuwa E, Kobayashi H, Terasaka S, Houkin K. Primary pineal rhabdomyosarcoma successfully treated by high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation: case report. J Neurosurg Pediatr. 2016; 18: 41-5.
5) Umeda K, Adachi S, Tanaka S, Miki M, Okada K, Hashii Y, Inoue M, Cho Y, Koh K, Goto H, Kajiwara R, Hyakuna N, Kato K, Morio T, Yabe H; Inherited Disease Working Group of the Japan Society for Hematopoietic Cell Transplantation. Comparison of second transplantation and donor lymphocyte infusion for donor mixed chimerism after allogeneic stem cell transplantation for nonmalignant diseases. Pediatr Blood Cancer. 2016; 63: 2221-2229.
6) Sakaguchi H, Watanabe N, Matsumoto K, Yabe H, Kato S, Ogawa A, Inagaki J, Goto H, Koh K, Yoshida N, Kato K, Cho Y, Kosaka Y, Takahashi Y, Inoue M, Kato K, Atsuta Y, Miyamura K; Donor/Source Working Group of Japan Society of Hematopoietic Cell Transplantation. Comparison of Donor Sources in Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Nationwide Retrospective Study. Biol Blood Marrow Transplant. 2016; 22: 2226-2234.
7) Wlodarski MW, Hirabayashi S, Pastor V, Starý J, Hasle H, Masetti R, Dworzak M, Schmugge M, van den Heuvel-Eibrink M, Ussowicz M, De Moerloose B, Catala A, Smith OP, Sedlacek P, Lankester AC, Zecca M, Bordon V, Matthes-Martin S, Abrahamsson J, Kühl JS, Sykora KW, Albert MH, Przychodzien B, Maciejewski JP, Schwarz S, Göhring G, Schlegelberger B, Cseh A, Noellke P, Yoshimi A, Locatelli F, Baumann I, Strahm B, Niemeyer CM; EWOG-MDS. Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents. Blood. 2016; 127: 1387-97
8) Pastor V, Hirabayashi S, Karow A, Wehrle J, Kozyra EJ, Nienhold R, Ruzaike G, Lebrecht D, Yoshimi A, Niewisch M, Ripperger T, Göhring G, Baumann I, Schwarz S, Strahm B, Flotho C, Skoda RC, Niemeyer CM, Wlodarski MW. Mutational landscape in children with myelodysplastic syndromes is distinct from adults: specific somatic drivers and novel germline variants. Leukemia. 2017; 31: 759-762
9) Hirabayashi S, Ohki K, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, Yaguchi A, Terada K, Saito Y, Yoshimi A, Ogata-Kawata H, Sakamoto H, Kato M, Fujimura J, Hino M, Kinoshita A, Kakuda H, Kurosawa H, Kato K, Kajiwara R, Moriwaki K, Morimoto T, Nakamura K, Noguchi Y, Osumi T, Sakashita K, Takita J, Yuza Y, Matsuda K, Yoshida T, Matsumoto K, Hata K, Kubo M, Matsubara Y, Fukushima T, Koh K, Manabe A, Ohara A, Kiyokawa N; Tokyo Children’s Cancer Study Group (TCCSG). ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype. Haematologica. 2017; 102: 118-129
10) Speckmann C, Sahoo SS, Rizzi M, Hirabayashi S, Karow A, Serwas NK, Hoemberg M, Damatova N, Schindler D, Vannier JB, Boulton SJ, Pannicke U, Göhring G, Thomay K, Verdu-Amoros JJ, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl SR, Niemeyer C, Boztug K, Wlodarski MW. Clinical and Molecular Heterogeneity of RTEL1 Deficiency. Front Immunol. 2017; 8: 449
11) Hirabayashi S, Seki M, Hasegawa D, Kato M, Hyakuna N, Shuo T, Kimura S, Yoshida K, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Kiyokawa N, Miyano S, Ogawa S, Takita J, Manabe A. Constitutional abnormalities of IDH1 combined with secondary mutations predispose a patient with Maffucci syndrome to acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017; 64: e26772
12) Hirabayashi S, Wlodarski MW, Kozyra E, Niemeyer CM. Heterogeneity of GATA2-related myeloid neoplasms. Int J Hematol. 2017; 106: 175-182
13) Iguchi A, Cho Y, Sugiyama M, Terashita Y, Ariga T, Hosoya Y, Hirabayashi S, Manabe A, Hara K, Aiba T, Shiokawa T, Tada H, Sato N. Bortezomib combined with standard induction chemotherapy in Japanese children with refractory acute lymphoblastic leukemia. Int J Hematol 2017; 106: 291-298.
14) Tsujioka T, Sugiyama M, Ueki M, Tozawa Y, Takezaki S, Ohshima J, Cho Y, Yamada M, Iguchi A, Kobayashi I, Ariga T. Difficulty in the diagnosis of bone and joint pain associated with pediatric acute leukemia; comparison with juvenile idiopathic arthritis. Mod Rheumatol. 2017; 28: 108-113
15) Sugiyama M, Iguchi A, Yamada M, Terashita Y, Ohshima J, Cho Y, Miyake N, Matsumoto N, Ueki M, Yamazaki Y, Takezaki S, Kobayashi I, Ariga T. Successful bone marrow transplantation in two sisters with activated phosphoinositide 3-kinase δ syndrome 2. Bone Marrow Transplant. 2017; 52: 1678-1680.
16) Leiding JW, Okada S, Hagin D, Abinun M, Shcherbina A, Balashov DN, Kim VHD, Ovadia A, Guthery SL, Pulsipher M, Lilic D, Devlin LA, Christie S, Depner M, Fuchs S, van Royen-Kerkhof A, Lindemans C, Petrovic A, Sullivan KE, Bunin N, Kilic SS, Arpaci F, Calle-Martin O, Martinez-Martinez L, Aldave JC, Kobayashi M, Ohkawa T, Imai K, Iguchi A, Roifman CM, Gennery AR, Slatter M, Ochs HD, Morio T, Torgerson TR; Inborn Errors Working Party of EBMT and the PIDTC. Hematopoietic stem cell transplantation in patients with Gain of Function STAT1 Mutation. J Allergy Clin Immunol. 2018; 141: 704-717
17) Isobe T, Seki M, Yoshida K, Sekiguchi M, Shiozawa Y, Shiraishi Y, Kimura S, Yoshida M, Inoue Y, Yokoyama A, Kakiuchi N, Suzuki H, Kataoka K, Sato Y, Kawai T, Chiba K, Tanaka H, Shimamura T, Kato M, Iguchi A, Hama A, Taguchi T, Akiyama M, Fujimura J, Inoue A, Ito T, Deguchi T, Kiyotani C, Iehara T, Hosoi H, Oka A, Sanada M, Tanaka Y, Hata K, Miyano S, Ogawa S, Takita J. Integrated molecular characterization of the lethal pediatric cancer pancreatoblastoma Cancer Res. 2018; 78: 865-876
18) Sekimizu M, Iguchi A, Mori T, Koga Y, Kada A, Saito AM, Horibe K. Phase I clinical study of brentuximab vedotin (SGN-35) involving children with recurrent or refractory CD30-positive Hodgkin's lymphoma or systemic anaplastic large cell lymphoma: rationale, design and methods of BV-HLALCL study: study protocol. BMC Cancer. 2018; 18: 122.
19) Mai Y, Ujiie H, Iguchi A, Shimizu H. A case of red lunulae after haematopoietic stem cell transplantation. Eur J Dermatol. 2018; 28: 407-409
20) Iesato K, Hori T, Yoto Y, Yamamoto M, Inazawa N, Kamo K, Ikeda H, Iyama S, Hatakeyama N, Iguchi A, Sugita J, Kobayashi R, Suzuki N, Tsutsumi H. Long-term prognosis of patients with HHV-6 reactivation following allogeneic HSCT. Pediatr Int. 2018; 60: 547-552
21) Asahi Y, Honda S, Okada T, Miyagi H, Kaneda M, Iguchi A, Kaga K, Taketomi A. Usefulness of Plain Computed Tomography with Swallowing of GastrografinTM for the Diagnosis of a Late-Onset Iatrogenic Diaphragmatic Hernia following Biopsy of a Diaphragmatic Tumor: Report of a Case. Case Rep Gastroenterol 2018; 12: 271–276
22) Sugiyama M, Iguchi A, Terashita Y, Ohshima J, Cho Y. Povidone-iodine lowers incidence of catheter-associated bloodstream infections. Pediatr Int. 2019; 61: 230-234
23) Ishida H, Iguchi A, Aoe M, Takahashi T, Tamefusa K, Kanamitsu K, Fujiwara K, Washio K, Matsubara T, Tsukahara H, Sanada M, Shimada A. Panel-based next-generation sequencing identifies prognostic and actionable genes in childhood acute lymphoblastic leukemia and is suitable for clinical sequencing. Ann Hematol. 2019; 98: 657-668.
24) Yoshikawa T, Ihira M, Higashimoto Y, Hattori F, Miura H, Sugata K, Komoto S, Taniguchi K, Iguchi A, Yamada M, Ariga T. Persistent systemic rotavirus vaccine infection in a child with X-linked severe combined immunodeficiency. J Med Virol. 2019; 91: 1008-1013
25) Fujino H, Ishida H, Iguchi A, Onuma M, Kato K, Shimizu M, Yasui M, Fujisaki H, Hamamoto K, Washio K, Sakaguchi H, Miyashita E, Osugi Y, Nakagami-Yamaguchi E, Hayakawa A, Sato A, Takahashi Y, Horibe K. High rates of ovarian function preservation after hematopoietic cell transplantation with melphalan-based reduced intensity conditioning for pediatric acute leukemia: an analysis from the Japan Association of Childhood Leukemia Study (JACLS). Int J Hematol. 2019, 109: 578-583
26) Hashimoto T, Shimizu S, Takao S, Terasaka S, Iguchi A, Kobayashi H, Mori T, Yoshimura T, Matsuo Y, Tamura M, Matsuura T, Ito YM, Onimaru R, Shirato H. Clinical experience of craniospinal intensity-modulated spot-scanning proton therapy using large fields for central nervous system medulloblastomas and germ cell tumors in children, adolescents, and young adults. J Radiat Res. 2019; 60: 527-537
27) Iguchi A, Cho Y, Yabe H, Kato S, Kato K, Hara J, Koh K, Takita J, Ishihara T, Inoue M, Imai K, Nakayama H, Hashii Y, Morimoto A, Atsuta Y, Morio T; Hereditary disorder Working Group of the Japan Society for Hematopoietic Cell Transplantation. Long-term outcome and chimerism in patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation: a retrospective nationwide survey. Int J Hematol. 2019; 110: 364–369.
28) Tomizawa D, Yoshida M, Kondo T, Miyamura T, Taga T, Adachi S, Koh K, Noguchi M, Kakuda H, Watanabe K, Cho Y, Fukuda T, Kato M, Shiba N, Goto H, Okada K, Inoue M, Hashii Y, Atsuta Y, Ishida H. Allogeneic hematopoietic stem cell transplantation for children and adolescents with high-risk cytogenetic AML: distinctly poor outcomes of FUS-ERG-positive cases. Bone Marrow Transplant 2019; 54(3): 393-401,
29) Kato M, Kurata M, Kanda J, Kato K, Tomizawa D, Kudo K, Yoshida N, Watanabe K, Shimada H, Inagaki J, Koh K, Goto H, Kato K, Cho Y, Yuza Y, Ogawa A, Okada K, Inoue M, Hashii Y, Teshima T, Murata M, Atsuta Y. Impact of graft-versus-host disease on relapse and survival after allogeneic stem cell transplantation for pediatric leukemia. Bone Marrow Transplant 2019; 54(1): 68-75
30) Sugiyama M, Terashita Y, Hara K, Cho Y, Iguchi A, Chin S, Manabe A. Corticosteroid-induced glaucoma in pediatric patients with hematological malignancies. Pediatr Blood Cancer. 66(12):e27977, 2019
31) Ohki K, Kiyokawa N, Saito Y, Hirabayashi S, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, Yoshimi A, Ogata-Kawata H, Sakamoto H, Kato M, Fukushima K, Hasegawa D, Fukushima H, Imai M, Kajiwara R, Koike T, Komori I, Matsui A, Mori M, Moriwaki K, Noguchi Y, Park MJ, Ueda T, Yamamoto S, Matsuda K, Yoshida T, Matsumoto K, Hata K, Kubo M, Matsubara Y, Takahashi H, Fukushima T, Hayashi Y, Koh K, Manabe A, Ohara A; Tokyo Children’s Cancer Study Group (TCCSG). Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion. Haematologica. 2019; 104: 128-137
32) Hirabayashi S, Hasegawa D, Yamamoto K, Nishimura A, Hosoya Y, Shuo T, Kiyokawa N, Miura M, Takahashi N, Manabe A. Dasatinib and low-intensity chemotherapy for Philadelphia chromosome-positive acute lymphoblastic leukemia in a child with Down syndrome. Pediatr Blood Cancer. 2019; 66: e27612
33) Nishimura A, Hasegawa D, Hirabayashi S, Kanabuchi S, Yamamoto K, Aiga S, Nishitani M, Hosoya Y, Noguchi Y, Ohki K, Kiyokawa N, Mori S, Manabe A. Very late relapse cases of TCF3-ZNF384-positive acute lymphoblastic leukemia. Pediatr Blood Cancer. 2019: e27891
34) Ukeba-Terashita Y, Kobayashi R, Hori D, et al. Long-term outcome of renal function in children after stem cell transplantation measured by estimated glomerular filtration rate. Pediatr Blood Cancer.2019; 66(2): e27478
35) Akazawa Y, Hosono A, Yoshikawa T, Kaneda H, Nitani C, Hara J, Kinoshita Y, Kohashi K, Manabe A, Fukutani M, Wakabayashi M, Sato A, Shoda K, Shimomura M, Mizuno S, Nakamoto Y, Nakatsura T. Efficacy of the NCCV Cocktail-1 vaccine for refractory pediatric solid tumors: A phase I clinical trial. Cancer Sci. 2019; 110 (12): 3650-3662.
36) Ishimaru S, Okamoto Y, Imai C, Sakaguchi H, Taki T, Hasegawa D, Cho Y, Kakuda H, Sano H, Manabe A, Imamura T, Kato M, Arakawa Y, Shimonodan H, Sato A, Suenobu S, Inukai T, Watanabe A, Kawano Y, Kikuta A, Horibe K, Ohara A, Koh K. Nationwide survey of pediatric hypodiploid acute lymphoblastic leukemia in Japan. Pediatr Int. 2019; 61(11): 1103-1108
37) Hasegawa D, Yoshimoto Y, Kimura S, Kumamoto T, Maeda N, Hara J, Kikuta A, Kada A, Kimura T, Iijima-Yamashita Y, Saito AM, Horibe K, Manabe A, Ogawa C. Bortezomib-containing therapy in Japanese children with relapsed acute lymphoblastic leukemia. Int J Hematol. 2019; 110(5): 627-634.
38) Nakano Y, Tsunematsu Y, Yamazaki F, Manabe A, Nakagawara A, Hiyama E, Kumamoto T. Pediatric patients with cancer predisposition in Japan: Results of a questionnaire survey. Pediatr Blood Cancer. 2019; 66(10): e27937.
39) Kimura S, Hasegawa D, Yoshimoto Y, Seki M, Daida A, Sekiguchi M, Hirabayashi S, Hosoya Y, Kobayashi M, Miyano S, Ogawa S, Takita J, Manabe A. Duplication of ALK F1245 missense mutation due to acquired uniparental disomy associated with aggressive progression in a patient with relapsed neuroblastoma. Oncol Lett. 2019; 17(3): 3323-3329.
40) Miyamura T, Moritake H, Nakayama H, Tanaka S, Tomizawa D, Shiba N, Saito AM, Tawa A, Shimada A, Iwamoto S, Hayashi Y, Koike T, Horibe K, Manabe A, Mizutani S, Taga T, Adachi S. Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. Br J Haematol. 2019; 185(2): 284-288.
41) Hasegawa D, Yoshimoto Y, Kimura S, Kumamoto T, Maeda N, Hara J, Kikuta A, Kada A, Kimura T, Iijima-Yamashita Y, Saito AM, Horibe K, Manabe A, Ogawa C. Bortezomib-containing therapy in Japanese children with relapsed acute lymphoblastic leukemia. Int J Hematol. 2019; 110(5): 627-634.
42) Kanda J, Umeda K, Kato K, Murata M, Sugita J, Adachi S, Koh K, Noguchi M, Goto H, Yoshida N, Sato M, Koga Y, Hori T, Cho Y, Ogawa A, Inoue M, Hashii Y, Atsuta Y, Teshima T; JSHCT GVHD Working Group. Effect of graft-versus-host disease on outcomes after pediatric single cord blood transplantation. Bone Marrow Transplant. 55(7), 1430-1437, 2020
43) Sugiyama M, Terashita Y, Hara K, Cho Y, Asano T, Iguchi A. Septic arthritis caused by Mycobacterium kansasii in a bone marrow transplant recipient. J pediatr Hematol Oncol. 42(8), e791-794, 2020
44) Umeda K, Imai K, Yanagimachi M, Yabe H, Kobayashi M, Takahashi Y, Kajiwara M, Yoshida N, Cho Y, Inoue M, Hashii Y, Atsuta Y, Morio T; Inherited Disease Working Group of the Japan Society for Hematopoietic Cell Transplantation. Impact of graft-versus-host disease on the clinical outcome of allogeneic hematopoietic stem cell transplantation for non-malignant diseases. Int J Hematol. 111(6):869-876, 2020
45) Chida-Nagai A, Sagawa K, Tsujioka T, Fujimoto T, Taniguchi K, Sasaki O, Izumi G, Yamazawa H, Masaki N, Manabe A, Takeda A. Pulmonary vasodilators can lead to various complications in pulmonary "arterial" hypertension associated with congenital heart disease. Heart Vessels. 35(9):1307-1315, 2020
46) Kimura S, Seki M, Kawai T, Goto H, Yoshida K, Isobe T, Sekiguchi M, Watanabe K, Kubota Y, Nannya Y, Ueno H, Shiozawa Y, Suzuki H, Shiraishi Y, Ohki K, Kato M, Koh K, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Manabe A, Sanada M, Mansour M, Ohara A, Horibe K, Kobayashi M, Oka A, Hayashi Y, Miyano S, Hata K, Ogawa S, Takita J: DNA methylation-based classification reveals difference between pediatric T-cell acute lymphoblastic leukemia and normal thymocytes. Leukemia 34:1163-1168, 2020
47) Sugiyama M, Terashita Y, Takeda A, Iguchi A, Manabe A: Immune thrombocytopenia in a case of trisomy 18. Pediatr Int 62:240-242, 2020
48) Sugiyama M, Terashita Y, Cho Y, Iguchi A, Arai R, Takakuwa E, Honda S, Manabe A: Successful treatment of dumbbell-shaped Hodgkin lymphoma with massive sacral bone destruction. Pediatr Blood Cancer 67:e28210, 2020
49) Sugiyama M, Kinuya S, Hosoya Y, Iguchi A, Manabe A: 131I-MIBG therapy with WT-1 peptide for refractory neuroblastoma. Pediatr Int 62:746-747, 2020
50) Takaoka K, Koya J, Yoshimi A, Toya T, Kobayashi T, Nannya Y, Nakazaki K, Arai S, Ueno H, Usuki K, Yamashita T, Imanishi D, Sato S, Suzuki K, Harada H, Manabe A, Hayashi Y, Miyazaki Y, Kurokawa M: Nationwide epidemiological survey of familial myelodysplastic syndromes/acute myeloid leukemia in Japan: A multicenter retrospective study. Leukemia Lymphoma 61:1688-1694, 2020
51) Sakaguchi K, Imamura T, Ishimaru S, Imai C, Shimonodan H, Fujita N, Okada K, Taketani T, Kanai R, Tauchi H, Kato M, Kojima Y, Watanabe A, Deguchi T, Hashii Y, Kiyokawa N, Taki T, Saito AM, Horibe K, Manabe A, Sato A, Koh K: Nationwide study of pediatric B-cell precursor acute lymphoblastic leukemia with chromosome 8q24/MYC rearrangement in Japan. Pediatr Blood Cancer 67:e28341, 2020
52) Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C, Rives S, Carlavilla MdP, Alonso MEV, Pinilla ND, Bourquin JP, Schmiegelow K, Attarbaschi A, Grillner P, Mellgren K, van der Werff JTB, Pieters R, Brozou T, Borkhardt A, Escherich G, Lauten M, Stanulla M, Smith O, Yeoh AEJ, Elitzur S, Vora A, Li CK, Ariffin H, Kolenova A, Dallapozza L, Farah R, Lazic J, Manabe A, Styczynski J, Kovacs G, Ottoffy G, Felice M, Buldini B, Conter V, Stary J, Schrappe M: Flash survey on SARS-CoV-2 infections in pediatric patients on anti-cancer treatment. Eur J Cancer 132:11-16, 2020
53) Ohki K, Takahashi H, Fukushima T, Nanmoku T, Kusano S, Mori M, Nakazawa Y, Yuza Y, Migita M, Okuno H, Morimoto A, Yoshino H, Kato M, Hayashi Y, Manabe A, Ohara A, Hasegawa D, Inukai T, Tomizawa D, Koh K, Kiyokawa N: Impact of immunophenotypic characteristics on genetic subgrouping in childhood acute lymphoblastic leukemia: Tokyo Children’s Cancer Study Group (TCCSG) study L04-16. Genes Chromosomes Cancer 59:551-561, 2020
54) Iehara T, Manabe A, Hosoi H: Statement on the prevention and treatment of COVID-19 in patients with pediatric cancer in Japan. Pediatr Blood Cancer 67:e28440, 2020
55) Ishida H, Miyajima Y, Hyakuna N, Hamada S, Sarashina T, Matsumura R, Umeda K, Mitsui T, Fujita N, Tomizawa D, Urayama KY, Ishida Y, Taga T, Takagi M, Adachi S, Manabe A, Imamura T, Koh K, Shimada A: Clinical features of children with polycythaemia vera, essential thrombocythemia, and primary myelofibrosis in Japan: A retrospective nationwide survey. eJHaem 1:86-93, 2020
56) Yoshida N, Sakaguchi H, Yabe M, Hasegawa D, Hama A, Hasegawa D, Kato M, Noguchi M, Terui K, Takahashi Y, Cho Y, Sato M, Koh K, Kakuda H, Shimada H, Hashii Y, Sato A, Kato K, Atsuta Y, Watanabe K; Pediatric Myelodysplastic Syndrome Working Group of the Japan Society for Hematopoietic Cell Transplantation. Clinical Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation in Children with Juvenile Myelomonocytic Leukemia: A Report from the Japan Society for Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 26(5), 902-910, 2020
57) Tomizawa D, Miyamura T, Imamura T, Watanabe T, Saito AM, Ogawa A, Takahashi Y, Hirayama M, Taki T, Deguchi T, Hori T, Sanada M, Ohmori S, Haba M, Iguchi A, Arakawa Y, Koga Y, Manabe A, Horibe K, Ishii E, Koh K: A risk-stratified therapy for infants with acute lymphoblastic leukemia: a report from the JPLSG MLL-10 trial. Blood 136:1813-1823, 2020
58) Yasuda T, Sanada M, Nishijima D, Kanamori T, Iijima Y, Hattori H, Saito A, Miyoshi H, Ishikawa Y, Asou N, Usuki K, Hirabayashi S, Kato M, Ri M, Handa H, Ishida T, Shibayama H, Abe M, Iriyama C, Karube K, Nishikori M, Ohshima K, Kataoka K, Yoshida K, Shiraishi Y, Goto H, Adachi S, Kobayashi R, Kiyoi H, Miyazaki Y, Ogawa S, Kurahashi H, Yokoyama H, Manabe A, Iida S, Tomita A, Horibe K: Clinical utility of target capture-based panel sequencing in hematological malignancies: a multicenter feasibility study. Cancer Sci 111:3367-3378, 2020
59) Nakajima S, Sato I, Soejima T, Koh K, Kato M, Okamoto Y, Imamura T, Maeda M, Ishida Y, Manabe A, Kamibeppu K: Comparison of child and family reports of health-related quality of life in pediatric acute lymphoblastic leukemia patients after induction therapy. BMC Pediatr 20:390, 2020
60) Kumamoto T, Goto H, Ogawa C, Hori T, Deguchi T, Araki T, Saito AM, Manabe A, Horibe K, Toyoda H: FLEND (nelarabine, fludarabine, and etoposide) for relapsed T-cell acute lymphoblastic leukemia in children: a report from Japan Children’s Cancer Group. Int J Hematol 112:720-724, 2020
61) Ueno H, Yoshida K, Shiozawa Y, Nannya Y, Iijima-Yamashita Y, Kiyokawa N, Shiraishi Y, Chiba K, Tanaka H, Isobe T, Seki M, Kimura S, Makishima H, Nakagawa M, Kakiuchi N, Kataoka K, Yoshizato T, Nishijima D, Deguchi T, Ohki K, Sato A, Takahashi H, Hshii Y, Tokimasa S, Hara J, Kosaka Y, Kato K, Inukai T, Takita J, Imamura T, Miyano S, Manabe A, Horibe K, Ogawa S, Sanada M: Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia. Blood Adv 4:5165-5173, 2020
62) Nishimura A, Hirabayashi S, Hasegawa D, Yoshida K, Shiraishi Y, Ashiarai M, Hosoya Y, Fujiwara T, Harigae H, Miyano S, Ogawa S, Manabe A: Acquisition of monosomy 7 and a RUNX1 mutation in Pearson syndrome. Pediatr Blood Cancer 68:e28799, 2021
63) Ono R, Ashiarai M,Hirabayashi S, Mizuki K, Hosoya Y, Yoshihara H, Ohtake J, Mori S, Manabe A, Hasegawa D: Ruxolitinib for hematopoietic cell transplantation-associated hemophagocytic lymphohistiocytosis. Int J Hematol 113:297-301, 2021
64) Nakagawa S, Kato M, Imamura T, Imai C, Koh K, Kawano Y, Shimomura Y, Watanabe A, Kikuta A, Saito A, Horibe K, Manabe A, Ohara A, Okamoto Y: In-hospital management might reduce induction deaths in pediatric patients with acute lymphoblastic leukemia: Results from a Japanese cohort. J Pediatr Hematol Oncol 43:39-46, 2021
65) Hirabayashi S, Butler ER, Ohki K, Kiyokawa N, Bergmann AK, Möricke A, Boer JM, Cavé H, Cazzaniga G, Yeoh AEJ, Sanada M, Imamura T, Inaba H, Mullighan C, Loh ML, Norén-Nyström U, Pastorczak A, Shih LY, Zaliova M, Pui CH, Haas OA, Harrison CJ, Moorman AV, Manabe A: Clinical characteristics and outcomes of B-ALL with ZNF384 rearrangements: A retrospective analysis by the Ponte di Legno Childhood ALL Working Group. Leukemia, in press
66) Arakawa A,Ichikawa H, Kubo T, Motoi N, Kumamoto T, Nakajima M, Yonemori K, Noguchi E, Sunami K, Shiraishi K, Kakishima H, Yoshida H, Hishiki T, Kawakubo N, Kuroda T, Kiyokawa T, Yamada K, Yanaihara N, Takahashi K, Okamoto A, Hirabayashi S, Hasegawa D, Manabe A, Ono K, Matsuoka M, Arai Y, Togashi Y, Shibata T, Nishikawa H, Aoki K, Yamamoto N, Kohno T, Ogawa C: Vaginal transmission of cancer from mothers with cervical cancer to infants. N Engl J Med 384:42-50, 2021
67) Tanaka Y, Yeoh AEJ, Moriyama T, Li CK, Kudo K, Arakawa Y, Buaboonnam J, Zhang H, Liu HC, Ariffin H, Chen Z, Kham S, Nishii R, Hasegawa D, Fujimura J, Keino D, Kondoh K, Sato A, Ueda T, Yamamoto M, Taneyama Y, Hino M, Takagi M, Ohara A, Ito E, Koh K, Hori H, Manabe A, Yang JJ, Kato M: An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 biallelic variants in children with acute lymphoblastic leukemia. Haematologica, in press
68) Kikuchi J, Ohhara Y, Takada K, Tanabe H, Hatanaka K, Amano T, Hatanaka K, Hatanaka Y, Mitsumura T, Kato M, Shibata Y, Yabe I, Endoh A, Komatsu Y, Matsuno Y, Sugiyama M, Manabe A, Sakurai A, Takahashi M, Naruse H, Torimoto Y, Akita HD, Kinoshita I: Clinical significance of comprehensive genomic profiling tests covered by public insurance in patients with advanced solid cancers in Hokkaido, Japan Jpn J Clin Oncol hyaa277, 2021
69) Ishi Y, Shimizu A, Takakuwa E, Sugiyama M, Okamoto M, Motegi H, Hirabayashi S, Cho Y, Iguchi A, Manabe A, Nobusawa S, Tanaka S, Yamaguchi S: High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report. Pathol Int, in press
70) Okamoto M, Yamaguchi S, Ishi Y, Motegi H, Mori T, Hashimoto T, Terashita Y, Hirabayashi S, Sugiyama M, Iguchi A, Cho Y, Manabe A, Houkin K.Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor. Oncology. 99(1):23-31, 2021
71) Kawahara Y, Morimoto A, Inagaki J, Koh K, Noguchi M, Goto H, Yoshida N, Cho Y, Hori T, Hiwatari M, Kato K, Ogawa A, Hashii Y, Inoue M, Kato K, Atsuta Y, Kimura F, Kato M. Unrelated cord blood transplantation with myeloablative conditioning for pediatric acute lymphoblastic leukemia in remission: prognostic factors. Bone Marrow Transplant. 56(2):357-367, 2021

国際会議等発表
(この他、国内でも積極的に学会に参加し発表を重ねています。)

1) Iguchi A, Sugiyama M, Terashita Y, Ohshima J, Sato T, Cho Y, Ariga T.
GVHD prophylaxis using MTX decreases pre-engraftment syndrome and accelerates engraftment after cord blood transplantation (CBT)
41th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT), March, 2015 (Istanbul, Turkey)
2) Sugiyama M, Terashita Y, Ohshima J, Cho Y, Iguchi A, The efficacy of tandem stem cell transplantation in patients with high-risk neuroblastoma. 41th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT), (Istanbul, Turkey), 2015/3/22-25
3) Sugiyama M, Terashita Y, Ohshima J, Cho Y, Iguchi A. Successful report of allogeneic unrelated bone marrow transplantation in a child with PIK3R1 deficiency. 42h Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT), (Valencia, Spain) 2016/4/3-6
4) Cho Y, Terashita Y, Sugiyama M, Ohshima J, Iguchi A, Ariga T
Hazards of inappropriate use of pentazocine; analysis of 10-years use of pantazocine for pain control in children with cancer.
48th Congress of the International Society of Paediatric Oncology (SIOP), October, 2016 (Dublin, Ireland)
5) Iguchi A, Cho Y, Yabe H, Kato S, Kato K, Inoue M, Imai K, Inagaki J, Hashii Y, Morimoto A, Atsuta Y, Morio T. Long-term outcome and chimerism in patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation: TRUMP data analysis in a collaborative study of The Japan Society for Hematopoietic Cell Transplantation. 43th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT), (Marseille, France) 2017/3/26-29
6) Cho Y, Terashita Y, Sugiyama M, Ohshima J, Sato T, Iguchi A, Ariga T
Characteristics of mediastinal neuroblastoma detected by chance in children older than 18-months in Japan.
49th Congress of the International Society of Paediatric Oncology (SIOP), October, 2017 (Washington DC, USA)
7) Cho Y, Sugiyama M, Terashita Y, Okubo J, Iguchi A. Usefulness of numbing medication for painful procedures in japan from the viewpoint of patients and medical professionals. 50th Congress of the International Society of Paediatric Oncology (SIOP), (Kyoto, Japan) 2018/11/16-19
8) Sugiyama M, Terashita Y, Okubo J, Cho Y, Iguchi A. Steroid-induced glaucoma in paediatric patients with acute leukaemia or malignant lymphoma. 50th Congress of the International Society of Paediatric Oncology (SIOP), (Kyoto, Japan)2018/11/16-19
9) Iguchi A, Sugiyama M, Terashita Y, Okubo J, Cho Y. Reconstitution of the immune system and incidences of infection after chemotherapy in patients with hematological malignancies. 50th Congress of the International Society of Paediatric Oncology (SIOP), (Kyoto, Japan)2018/11/16-19
10) Honda M, Terashita Y, Sugiyama M, Cho Y, Iguchi A. LONG-TERM OUTCOME FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION OF WISKOTT-ALDRICH SYNDROME IN A SINGLE INSTITUTE. 45thAnnual Meeting of European Society for Blood and Marrow Transplantation (EBMT), (Frankfurt, Germany) 2019/3/24-27
11) Iguchi A, Terashita Y, Sugiyama M, Honda M, Cho Y. CLINICAL EVALUATION OF IMMUNE RECONSTITUTION AND COMMUNITY-ACQUIRED INFECTION AFTER SCT. 45thAnnual Meeting of European Society for Blood and Marrow Transplantation (EBMT), (Frankfurt, Germany), 2019/3/24-27.
12) Terashita Y, Honda M, Sugiyama M, Cho Y, Iguchi A. SERUM LEVELS OF 5-S CYSTEINYLDOPA IS ASSOCIATED WITH STEM CELL TRANSPLANTATION RELATED COMPLICATIONS. 45thAnnual Meeting of European Society for Blood and Marrow Transplantation (EBMT), (Frankfurt, Germany), 2019/3/24-27