Message from the Professor

 Thank you for visiting the website of Department of Pediatrics, Hokkaido University.
 Department of Pediatrics, Hokkaido University was established in 1924. I was inaugurated as the 7th Professor on April 1, 2019, following Prof. Kazuo Nagai, Prof. Yoshifumi Ko, Prof. Naotatsu Yamada, Prof. Shuzo Matsumoto, Prof. Kunihiko Kobayashi, and Prof. Tadashi Ariga.
 Department of Pediatrics at Hokkaido University has dedicated specialized research groups in the following 10 areas: immunology, hematology / oncology, neurology, nephrology, endocrinology / diabetes, cardiology, neonatology, infectious diseases, genetics, and metabolism / gastroenterology. Patients with any kind of pediatric disease can receive appropriate diagnosis and treatment at our department.
 Our department is committed to world-class research and passionate education in each group. We have produced many excellent researchers and clinicians who are actively contributing to child welfare in all over the world. We hope that you will appreciate our enthusiasm for both basic and clinical research in pediatrics. We will follow the saying of Prof. Clark, be ambitious and be gentleman (or lady).

Medical staffs

Name Job title Specialty
Atsushi Manabe Professor of Pediatrics Hematology and Oncology
Nobuhisa Ishiguro Clinical professor of Infection Control Team Infectious diseases
Kazutoshi Cho Clinical professor of Perinatal Care Center Neonatology
Masafumi Yamada Associate professor of Pediatrics Immunology
Akihiro Iguchi Lecturer of Pediatrics Hematology and Oncology
Hideaki Shiraishi Lecturer of Pediatrics Neurology
Yuko Cho Assistant professor of Pediatrics Hematology and Oncology
Atsuhito Takeda Assistant professor of Pediatrics Cardiology
Kiyoshi Egawa Assistant professor of Pediatrics Neurology
Akie Nakamura Assistant professor of Pediatrics Endocrinology and Diabetes
Takayuki Okamoto Assistant professor of Pediatrics Nephrology
Yuta Furuse Assistant professor of Perinatal Care Center Neonatology
Kazuyori Yagyu Assistant professor of Psychiatry Neurology
Shinsuke Hirabayashi Project assistant professor of Pediatrics Hematology and Oncology
Minako Sugiyama Project assistant professor of Pediatrics Hematology and Oncology
Toshiyuki Takahashi Project assistant professor of Clinical Research and Medical Innovation Center Nephrology
Kiyotaka Kosugiyama Clinical fellow of Pediatrics Metabolism and Gastroenterology
Hirokuni Yamazawa Clinical fellow of Pediatrics Cardiology
Shunichiro Takezaki Clinical fellow of Pediatrics Immunology
Yuki Ueda Clinical fellow of Pediatrics Neurology
Gaku Izumi Clinical fellow of Pediatrics Cardiology
Yasuyuki Sato Clinical fellow of Pediatrics Nephrology
Ayako Nagai Clinical fellow of Pediatrics Cardiology
Masahiro Ueki Clinical fellow of Pediatrics Immunology
Takeshi Yamaguchi Clinical fellow of Pediatrics Endocrinology and Diabetes
Yukayo Terashita Clinical fellow of Pediatrics Hematology and Oncology
Nozomi Hishimura Clinical fellow of Pediatrics Endocrinology and Diabetes
Noriko Namatame Clinical fellow of Pediatrics Neurology
Midori Nakajima Postdoctoral fellow of Pediatrics Neurology

Clinical and research activity

◆ Immunology group
We were the first in Japan to successfully treat ADA deficiency with gene therapy. Nowadays, we treat and research primary immunodeficiency diseases, collagen diseases, and allergic diseases (especially food allergies). Most recently, we were the first to diagnose and report four Japanese patients with hereditary folate malabsorption caused by the same deep intronic mutation.

◆ Infectious diseases group
An outpatient clinic for pediatric infectious diseases is held once a week. In addition, we have taken on the duties of nosocomial infection control and consultation on infectious disease treatment. We also conduct clinical and basic research on emerging respiratory infections (human metapneumovirus, human bocavirus, and polyomaviridae) and clinical research on the efficacy of anti-influenza drugs.

◆ Hematology and oncology group
We focus on the diagnosis and treatment of pediatric hematological diseases and solid tumors. To date, a total of more than 300 patients have undergone hematopoietic stem cell transplantation in our group. Starting in 2016, proton beam therapy for pediatric cancer is now covered by insurance. More and more people are coming to see our group for proton beam therapy. We also conduct research to reduce pain and complications in the treatment of pediatric blood disorders and pediatric oncological diseases.

◆ Neurology group
We deal with all pediatric neurological disorders. We have a particular focus on addressing spastic disorders, genetic neurological disorders and developmental disabilities. In addition, we are working on the neurophysiology of pediatric epilepsy and the molecular genetics of Prader-Willi syndrome, Angelman syndrome, and chromosome 14 uniparental disomy.

◆ Nephrology group
We deal with all pediatric kidney diseases from infants to adolescents (hematuria and proteinuria found in school urine tests, nephrotic syndrome, IgA nephropathy, membranous nephropathy, membranous proliferative glomerulonephritis, purpura nephritis, congenital anomalies of the kidney and urinary tract, hereditary kidney disease, lupus nephritis, renal failure, etc.). We are also engaged in basic medical research to elucidate the mechanism of development of nephrotic syndrome and glomerulonephritis.

◆ Endocrinology and diabetes group
We treat a wide range of pediatric endocrine disorders (growth disorders, adolescent dyspuberty, thyroid disorders, pituitary disorders, calcium and vitamin D related disorders, sexual differentiation disorders, bone system disorders, diabetes, etc.). We are also working on comprehensive genetic analysis of congenital hypothyroidism, elucidation of the pathogenesis of novel congenital hypopituitarism, and genetic analysis of diseases that cause unexplained growth disorders.

◆ Cardiology group
As the core of pediatric cardiovascular care in Hokkaido, we perform about 160 cardiac catheterization and/or treatment cases per year and about 120 pre-operative and post-operative management for cardiac surgeries per year. Furthermore, we are actively involved in the treatment of adult congenital heart disease and provide cardiovascular care that supports patients throughout their lives. We are conducting basic medical research to elucidate the pathophysiological mechanisms and novel treatments for cardiomyopathy and pulmonary hypertension in collaboration with Faculty of Pharmaceutical Sciences. In addition, we are conducting clinical studies on cardiomyopathy, arrhythmias, fetal echocardiography and pulmonary hypertension.

◆ Neonatology group
We provide care for preterm and low birth weight babies and manage approximately 50 surgical cases per year. Patients with congenital heart disease, pediatric surgical disease, neurosurgical disease, and congenital malformation syndrome come to our NICU from all over Hokkaido.
 We are also conducting 1) research on hereditary interstitial lung disease, 2) development of a light environment that promotes sleep and physical development in preterm infants, 3) research on the effects of endocrine disruptors on the fetus, and 4) evaluation of fetal heart failure using amniotic fluid brain natriuretic peptide (BNP).

◆ Genetics group
Twice a month, we offer outpatient services for the diagnosis, genetic testing, and genetic counseling of chromosomal anomalies, regular checkups for children with chromosomal anomalies, diagnosis, treatment, and genetic counseling of congenital malformation syndrome and other congenital anomalies.
 We are collaborating with other institutions to study genetic abnormalities and treatments for congenital malformation syndromes (especially Beckwith-Wiedemann syndrome, Prader-Willi syndrome, Silver-Russell syndrome, Williams syndrome, Kabuki syndrome, Down syndrome, and Noonan syndrome).

◆ Metabolism and gastroenterology group
We treat from the very rare inborn metabolic abnormalities to the very common habitual constipation. As a general rule, an appointment is required for outpatient consultations. Please call the Hokkaido University Hospital Pediatrics Outpatient Center in advance.
 We also conduct research on the diagnosis and treatment of congenital metabolic abnormalities and the diagnosis and treatment of gastrointestinal liver disease.