業績集

令和2（2020）年度

2020年度研究費取得状況

平成31（2019）年度

論文・著書など

論文（欧文）

1. Sugiyama M, Iguchi A, Terashita Y, Ohshima J, Cho Y. Povidone-iodine lowers incidence of catheter-associated bloodstream infections. Pediatr Int 2019; 61: 230-234.
2. Ishida H, Iguchi A, Aoe M, Takahashi T, Tamefusa K, Kanamitsu K, Fujiwara K, Washio K, Matsubara T, Tsukahara H, Sanada M, Shimada A. Panel-based next-generation sequencing identifies prognostic and actionable genes in childhood acute lymphoblastic leukemia and is suitable for clinical sequencing. Ann Hematol 2019; 98: 657-668.
3. Yoshikawa T, Ihira M, Higashimoto Y, Hattori F, Miura H, Sugata K, Komoto S, Taniguchi K, Iguchi A, Yamada M, Ariga T. Persistent systemic rotavirus vaccine infection in a child with X-linked severe combined immunodeficiency. J Med Virol 2019; 91: 1008-1013.
4. Fujino H, Ishida H, Iguchi A, Onuma M, Kato K, Shimizu M, Yasui M, Fujisaki H, Hamamoto K, Washio K, Sakaguchi H, Miyashita E, Osugi Y, Nakagami-Yamaguchi E, Hayakawa A, Sato A, Takahashi Y, Horibe K. High rates of ovarian function preservation after hematopoietic cell transplantation with melphalan-based reduced intensity conditioning for pediatric acute leukemia: an analysis from the Japan Association of Childhood Leukemia Study (JACLS). Int J Hematol 2019, 109: 578-583.
5. Hashimoto T, Shimizu S, Takao S, Terasaka S, Iguchi A, Kobayashi H, Mori T, Yoshimura T, Matsuo Y, Tamura M, Matsuura T, Ito YM, Onimaru R, Shirato H. Clinical experience of craniospinal intensity-modulated spot-scanning proton therapy using large fields for central nervous system medulloblastomas and germ cell tumors in children, adolescents, and young adults. J Radiat Res 2019; 60: 527-537.
6. Iguchi A, Cho Y, Yabe H, Kato S, Kato K, Hara J, Koh K, Takita J, Ishihara T, Inoue M, Imai K, Nakayama H, Hashii Y, Morimoto A, Atsuta Y, Morio T; Hereditary disorder Working Group of the Japan Society for Hematopoietic Cell Transplantation. Long-term outcome and chimerism in patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation: a retrospective nationwide survey. Int J Hematol 2019；110: 364–369.
7. Tomizawa D, Yoshida M, Kondo T, Miyamura T, Taga T, Adachi S, Koh K, Noguchi M, Kakuda H, Watanabe K, Cho Y, Fukuda T, Kato M, Shiba N, Goto H, Okada K, Inoue M, Hashii Y, Atsuta Y, Ishida H. Allogeneic hematopoietic stem cell transplantation for children and adolescents with high-risk cytogenetic AML: distinctly poor outcomes of FUS-ERG-positive cases. Bone Marrow Transplant 2019; 54(3): 393-401.
8. Kato M, Kurata M, Kanda J, Kato K, Tomizawa D, Kudo K, Yoshida N, Watanabe K, Shimada H, Inagaki J, Koh K, Goto H, Kato K, Cho Y, Yuza Y, Ogawa A, Okada K, Inoue M, Hashii Y, Teshima T, Murata M, Atsuta Y. Impact of graft-versus-host disease on relapse and survival after allogeneic stem cell transplantation for pediatric leukemia. Bone Marrow Transplant 2019; 54(1): 68-75.
9. Sugiyama M, Terashita Y, Hara K, Cho Y, Iguchi A, Chin S, Manabe A. Corticosteroid-induced glaucoma in pediatric patients with hematological malignancies. Pediatr Blood Cancer 2019 (in press)
10. Ohki K, Kiyokawa N, Saito Y, Hirabayashi S, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, Yoshimi A, Ogata-Kawata H, Sakamoto H, Kato M, Fukushima K, Hasegawa D, Fukushima H, Imai M, Kajiwara R, Koike T, Komori I, Matsui A, Mori M, Moriwaki K, Noguchi Y, Park MJ, Ueda T, Yamamoto S, Matsuda K, Yoshida T, Matsumoto K, Hata K, Kubo M, Matsubara Y, Takahashi H, Fukushima T, Hayashi Y, Koh K, Manabe A, Ohara A; Tokyo Children’s Cancer Study Group (TCCSG). Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion. Haematologica 2019; 104: 128-137.
11. Hirabayashi S, Hasegawa D, Yamamoto K, Nishimura A, Hosoya Y, Shuo T, Kiyokawa N, Miura M, Takahashi N, Manabe A. Dasatinib and low-intensity chemotherapy for Philadelphia chromosome-positive acute lymphoblastic leukemia in a child with Down syndrome. Pediatr Blood Cancer 2019; 66: e27612.
12. Nishimura A, Hasegawa D, Hirabayashi S, Kanabuchi S, Yamamoto K, Aiga S, Nishitani M, Hosoya Y, Noguchi Y, Ohki K, Kiyokawa N, Mori S, Manabe A. Very late relapse cases of TCF3-ZNF384-positive acute lymphoblastic leukemia. Pediatr Blood Cancer 2019: e27891.
13. Ukeba-Terashita Y, Kobayashi R, Hori D, et al. Long-term outcome of renal function in children after stem cell transplantation measured by estimated glomerular filtration rate. Pediatr Blood Cancer 2019; 66(2): e27478.
14. Akazawa Y, Hosono A, Yoshikawa T, Kaneda H, Nitani C, Hara J, Kinoshita Y, Kohashi K, Manabe A, Fukutani M, Wakabayashi M, Sato A, Shoda K, Shimomura M, Mizuno S, Nakamoto Y, Nakatsura T. Efficacy of the NCCV Cocktail-1 vaccine for refractory pediatric solid tumors: A phase I clinical trial. Cancer Sci 2019; 110 (12): 3650-3662.
15. Ishimaru S, Okamoto Y, Imai C, Sakaguchi H, Taki T, Hasegawa D, Cho Y, Kakuda H, Sano H, Manabe A, Imamura T, Kato M, Arakawa Y, Shimonodan H, Sato A, Suenobu S, Inukai T, Watanabe A, Kawano Y, Kikuta A, Horibe K, Ohara A, Koh K. Nationwide survey of pediatric hypodiploid acute lymphoblastic leukemia in Japan. Pediatr Int 2019; 61(11): 1103-1108.
16. Hasegawa D, Yoshimoto Y, Kimura S, Kumamoto T, Maeda N, Hara J, Kikuta A, Kada A, Kimura T, Iijima-Yamashita Y, Saito AM, Horibe K, Manabe A, Ogawa C. Bortezomib-containing therapy in Japanese children with relapsed acute lymphoblastic leukemia. Int J Hematol 2019; 110(5): 627-634.
17. Nakano Y, Tsunematsu Y, Yamazaki F, Manabe A, Nakagawara A, Hiyama E, Kumamoto T. Pediatric patients with cancer predisposition in Japan: Results of a questionnaire survey. Pediatr Blood Cancer 2019; 66(10): e27937.
18. Kimura S, Hasegawa D, Yoshimoto Y, Seki M, Daida A, Sekiguchi M, Hirabayashi S, Hosoya Y, Kobayashi M, Miyano S, Ogawa S, Takita J, Manabe A. Duplication of ALK F1245 missense mutation due to acquired uniparental disomy associated with aggressive progression in a patient with relapsed neuroblastoma. Oncol Lett 2019; 17(3): 3323-3329.
19. Miyamura T, Moritake H, Nakayama H, Tanaka S, Tomizawa D, Shiba N, Saito AM, Tawa A, Shimada A, Iwamoto S, Hayashi Y, Koike T, Horibe K, Manabe A, Mizutani S, Taga T, Adachi S. Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. Br J Haematol 2019; 185(2): 284-288.
20. Hasegawa D, Yoshimoto Y, Kimura S, Kumamoto T, Maeda N, Hara J, Kikuta A, Kada A, Kimura T, Iijima-Yamashita Y, Saito AM, Horibe K, Manabe A, Ogawa C. Bortezomib-containing therapy in Japanese children with relapsed acute lymphoblastic leukemia. Int J Hematol 2019; 110(5): 627-634.
21. Sugiyama M, Terashita Y, Cho Y, Iguchi A, Arai R, Takakuwa E, Honda S, Manabe A. Successful treatment of dumbbell-shaped Hodgkin lymphoma with massive sacral bone destruction. Pediatr Blood Cancer 2020 [Epub ahead of print]
22. Sugiyama M, Terashita Y, Hara K, Cho Y, Asano T, Iguchi A. Septic arthritis caused by Mycobacterium kansasii in a bone marrow transplant recipient. J pediatr Hematol Oncol 2020 [Epub ahead of print]
23. Sugiyama M, Kinuya S, Hosoya Y, Iguchi A, Manabe A. 131I-MIBG therapy with WT-1 peptide for refractory neuroblastoma. Pediatr Int 2020 [Epub ahead of print]
24. Sakaguchi K, Imamura T, Ishimaru S, Imai C, Shimonodan H, Fujita N, Okada K, Taketani T, Kanai R, Tauchi H, Kato M, Kojima Y, Watanabe A, Deguchi T, Hashii Y, Kiyokawa N, Taki T, Saito AM, Horibe K, Manabe A, Sato A, Koh K. Nationwide study of pediatric B-cell precursor acute lymphoblastic leukemia with chromosome 8q24/MYC rearrangement in Japan. Pediatr Blood Cancer 2020 [Epub ahead of print]
25. Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C, Rives S, Del Pozo Carlavilla M, Alonso MEV, Domínguez-Pinilla N, Bourquin JP, Schmiegelow K, Attarbaschi A, Grillner P, Mellgren K, van der Werff Ten Bosch J, Pieters R, Brozou T, Borkhardt A, Escherich G, Lauten M, Stanulla M, Smith O, Yeoh AEJ, Elitzur S, Vora A, Li CK, Ariffin H, Kolenova A, Dallapozza L, Farah , Lazic J, Manabe A, Styczynski J, Kovacs G, Ottoffy G, Felice MS, Buldini B, Conter V, Stary J, Schrappe M. Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. Eur J Cancer 2020 [Epub ahead of print]
26. Chida-Nagai A, Sagawa K, Tsujioka T, Fujimoto T, Taniguchi K, Sasaki O, Izumi G, Yamazawa H, Masaki N, Manabe A, Takeda A. Pulmonary vasodilators can lead to various complications in pulmonary "arterial" hypertension associated with congenital heart disease. Heart Vessels 2020 [Epub ahead of print]
27. Takaoka K, Koya J, Yoshimi A, Toya T, Kobayashi T, Nannya Y, Nakazaki K, Arai S, Ueno H, Usuki K, Yamashita T, Imanishi D, Sato S, Suzuki K, Harada H, Manabe A, Hayashi Y, Miyazaki Y, Kurokawa M. Nationwide epidemiological survey of familial myelodysplastic syndromes/acute myeloid leukemia in Japan: a multicenter retrospective study. Leuk Lymphoma 2020 [Epub ahead of print]
28. Sugiyama M, Terashita Y, Takeda A, Iguchi A, Manabe A. Immune thrombocytopenia in a case of trisomy 18. Pediatr Int 2020 [Epub ahead of print]
29. Kimura S, Seki M, Kawai T, Goto H, Yoshida K, Isobe T, Sekiguchi M, Watanabe K, Kubota Y, Nannya Y, Ueno H, Shiozawa Y, Suzuki H, Shiraishi Y, Ohki K, Kato M, Koh K, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Manabe A, Sanada M, Mansour MR, Ohara A, Horibe K, Kobayashi M, Oka A, Hayashi Y, Miyano S, Hata K, Ogawa S, Takita J. DNA methylation-based classification reveals difference between pediatric T-cell acute lymphoblastic leukemia and normal thymocytes. Leukemia 2020 [Epub ahead of print]
30. Tozawa Y*, Abdrabou SS*, Nogawa-Chida N*, Nishiuchi R, Ishida T, Suzuki Y, Sano H, Kobayashi R, Kishimoto K, Ohara O, Imai K, Naruto T, Kobayashi K, Ariga T, Yamada M*.(*: equal contribution) A deep intronic mutation of c.1166-285T>G in SLC46A1 is shared by four unrelated Japanese patients with hereditary folate malabsorption (HFM). Clin Immunol 2019;208:108256.
31. Yoshikawa T, Ihira M, Higashimoto Y, Hattori F, Miura H, Sugata K, Komoto S, Taniguchi K, Iguchi A, Yamada M, Ariga T. Persistent systemic rotavirus vaccine infection in a child with X-linked severe combined immunodeficiency. J Med Virol 2019;91:1008-1013.
32. Kobayashi I, Okura Y, Ueki M, Tozawa Y, Takezaki S, Yamada M and Ariga T: Evaluation of systemic activity of pediatric primary Sjögren's syndrome by EULAR Sjögren's syndrome disease activity index (ESSDAI). Mod Rheumatol 2019;29,130-133.
33. Ueki M, Kobayashi I, Takezaki S, Tozawa Y, Okura Y, Yamada M, Kuwana M and Ariga T: Myositis-specific autoantibodies in Japanese patients with juvenile idiopathic inflammatory myopathies. Mod Rheumatol 2019;29, 351-356.
34. Kobayashi I, Akioka S, Kobayashi N, Iwata N, Takezaki S, Nakaseko H, Sato S, Nishida Y, Nozawa T, Yamasaki Y, Yamazaki K, Arai S, Nishino I, Mori M. Clinical practice guidance for juvenile dermatomyositis (JDM) 2018-Update. Mod Rheumatol 2020;3:1-13.
35. Ishibashi M*, Egawa K*,Fukuda A. (*: equal contribution) Diverse Actions of Astrocytes in GABAergic Signaling. Int J Mol Sci 2019;20(12):2964.
36. Shiraishi H, Yamada K, Oki E, Ishige M, Fukao T, Hamada Y, Sakai N, Ochi F, Watanabe A, Kawakami S, Kuzume K, Watanabe K, Sameshima K, Nakamagoe K, Tamaoka A, Asahina N, Yokoshiki S, Miyakoshi T, Oba K, Isoe T, Hayashi H, Yamaguchi S, Sato N. Open-label clinical trial of bezafibrate treatment in patients with fatty acid oxidation disorders in Japan; 2nd report QOL survey. Mol Genet Metab Rep 2019; 20: 100496.
37. Hamada H, Suzuki H, Onouchi Y, et al.; KAICA trial Investigators(including Takeda A and Izumi G).Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial. Lancet 2019;393(10176):1128-1137.
38. Kijima R, Sasaki O, Shinmei Y, Ohguchi T, Takeda A, et al. Changes in Intraocular Pressure in Single Ventricle Patients After the Glenn or Fontan Procedure. J Glaucoma 2019;28(11):1012-1014.
39. Imai-Okazaki A, Kishita Y, Kohda M, Mizuno Y, Fushimi T, Matsunaga A, Yatsuka Y, Hirata T, Harashima H, Takeda A, et al.Cardiomyopathy in children with mitochondrial disease: Prognosis and genetic background.Int J Cardiol 2019;279:115-121.
40. Tsuneta S, Oyama-Manabe N, Takeda A, et al.The detection of retrograde flow from the left anterior descending artery into the main pulmonary artery by 4D-flow cardiac magnetic resonance in a patient with Bland-White-Garland syndrome. Eur Heart J Cardiovasc Imaging 2019;20(4):488.
41. Ueda Y, Takeda A, Kanno-Okada H, Aoyagi H. Dilated cardiomyopathy in an adolescent female with propionic acidemia. Journal of Pediatric Cardiology and Cardiac Surgery 2020;4(1):17-21.
42. Miura K, Sato Y, Yabuuchi T, Kaneko N, Ishizuka K, Chikamoto H, Akioka Y, Nawashiro Y, Hisano M, Imamura H, Miyai T, Sakamoto S, Kasahara M, Fuchinoue S, Okumi M, Ishida H, Tanabe K, Hattori M. Individualized concept for the treatment of autosomal recessive polycystic kidney disease with end-stage renal disease. Pediatr Transplant 2020 [Epub ahead of print]
43. Takahashi T, Okamoto T, Sato Y, Hayashi A, Ueda Y, Ariga T. Glucose metabolism disorders in children with refractory nephrotic syndrome. Pediatr Nephrol 2020;35(4):649-657.
44. Sato Y, Sasaki S, Okamoto T, Takahashi T, Hayashi A, Ogawa Y, Ariga T. Mesangial C4d deposition at diagnosis in childhood IgA nephropathy. Pediatr Int 2019;61(11):1133-1139.
45. Hamada S, Kato C, Takahashi T, Hayashi A, Ueda Y, Sato Y, Tonoki H, Okamoto T. A girl presenting with gradually elevated levels of serum creatinine: Answers. Pediatr Nephrol. 2020 [Epub ahead of print]
46. Hamada S, Kato C, Takahashi T, Hayashi A, Ueda Y, Sato Y, Tonoki H, Okamoto T. A girl presenting with gradually elevated levels of serum creatinine: Questions. Pediatr Nephrol. 2020 [Epub ahead of print]
47. Yatsuga S, Amano N, Nakamura-Utsunomiya A, Kobayashi H, Takasawa K, Nagasaki K, Nakamura A, Nishigaki S, Numakura C, Fujiwara I, Minamitani K, Hasegawa T, Toshihiro T. Clinical characteristics of cytochrome P450 oxidoreductase deficiency: a nationwide survey in Japan. Endocr J 2020 [Online ahead of print]
48. Sato T, Kojima T, Samura O, Kawaguchi S, Nakamura A, Nakajima M, Tanuma-Takahashi A, Nakagayashi K, Hata K, Ikegawa S, Nishimura G, Okamoto A, Yamada T. Two unrelated pedigrees with achondrogenesis type 1b carrying a Japan-specific pathogenic variant in SLC26A2. Am J Med Genet A 2020;182(4):735-739.
49. Katayama S, Iwata H, Nomura Y, Nakmura A, Yamaguchi T, Hishimura N, Nakayama K, Hashimoto K, Honda S, Shimizu H. Case of miliaria rubra histologically showing neutrophilic eccrine hidradentis due to hyperhidrosis induced by a catecholamine-producing neuroblastoma. J Dermatol 2020;47(3):e92-93.
50. Tajima T, Nakamura A, Oguma M, Yamazaki M. Recent advances in research on isolated congenital central hypothyroidism. Clin Pediatr Endocrinol 2019;28(3):69-79.
51. Insogna KL, Rauch F, Kamenický P, Ito N, Kubota T, Nakamura A, Zhang L, Mealiffe M, San Martin J, Portale AA. Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial. J Bone Miner Res 2019;34(12):2183-2191.
52. Kagami M, Yanagisawa A, Ota M, Matsuoka K, Nakamura A, Matsubara K, Nakabayashi K, Takada S, Fukami M, Ogata T. Temple syndrome in a patient with variably methylated CpGs at the primary MEG3/DLK1:IG-DMR and severely hypomethylated CpGs at the secondary MEG3:TSS-DMR. Clin Epigenetics 2019;11(1):42.
53. Suzuki E, Shima H, Kagami M, Soneda S, Tanaka T, Yatsuga S, Nishioka J, Oto Y, Kamiya T, Naiki Y, Ogata T, Fujisawa Y, Nakamura A, Kawashima S, Morikawa S, Horikawa R, Sano S, Fukami M. (Epi)genetic defects of MKRN3 are rare in Asian patients with central precocious puberty. Hum Genome Var 2019;6:7.
54. Yamaguchi T, Hachiya R, Watanabe-Yamamoto S, Sawano K, Morikawa S, Nakamura A, Hasegawa Y. Hypoglycemia in type 1A diabetes can develop before insulin therapy: A retrospective cohort study. Diabetes Res Clin Pract 2019;147:87-92.
55. Inoue T, Yagasaki H, Nishioka J, Nakamura A, Matsubara K, Narumi S, Nakabayashi K, Yamazawa K, Fuke T, Oka A, Ogata T, Fukami M, Kagami M. Molecular and clinical analyses of two patients with UPD(16)mat detected by screening 94 patients with Silver-Russell syndrome phenotype of unknown aetiology. J Med Genet 2019;56(6):413-418.
56. Kawanishi Y, Yoshioka E, Saijo Y, Itoh T, Miyamoto T, Sengoku K, Ito Y, Ito S, Miyashita C, Araki A, Endo T, Cho K, Minakami H, Kishi R; Japan Environment and Children’s Study Group. The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children's Study (JECS). PLoS One 2019;14(7):e0219379.
57. Kobayashi S, Kishi R, Saijo Y, Ito Y, Oba K, Araki A, Miyashita C, Itoh S, Minatoya M, Yamazaki K, Ait Bamai Y, Sato T, Yamazaki S, Nakayama SF, Isobe T, Nitta H; Japan Environment and Children's Study Group. Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children's Study: A prospective birth cohort. Environ Int 2019;125:418-429.
58. Nishimura Y, Moriya K, Kobayashi S, Araki A, Sata F, Mitsui T, Itoh S, Miyashita C, Cho K, Kon M, Nakamura M, Kitta T, Murai S, Kishi R, Shinohara N. Association between ESR1 polymorphisms and second to fourth digit ratio in school-aged children in the Hokkaido Study. Steroids 2019;141:55-62.
59. Ito K, Hanaoka T, Tamura N, Sasaki S, Miyashita C, Araki A, Ito S, Minakami H, Cho K, Endo T, Baba T, Miyamoto T, Sengoku K, Tamakoshi A, Kishi R. Association Between Maternal Serum Folate Concentrations in the First Trimester and the Risk of Birth Defects: The Hokkaido Study of Environment and Children's Health. J Epidemiol 2019;29(4):164-171.

論文（邦文）