業績集

令和5（2023）年度

2023年度研究費取得状況

論文・著書など

論文（欧文）

1. Abe J, Ueki M, Honjou R, Takeda K, Seto Y, Nakamura Y, Furuse Y, NakataK, Cho K. The clinical importance of pulmonary gene and proteinexpression levels in an infant with lethal ABCA3 variants. PediatrPulmonol. 2023 Oct;58(10):2956-2959. doi: 10.1002/ppul.26611. Epub 2023Jul 21. PMID: 37477506.
2. Arimitsu T, Fukutomi R, Kumagai M, Shibuma H, Yamanishi Y, TakahashiKI, Gima H, Seto Y, Adachi H, Arai H, HiguchiM, Ohgi S, Ohta H. Designing artificial circadian environments withmultisensory cares for supporting preterm infants' growth in NICUs.Front Neurosci. 2023 Aug 24;17:1152959. doi:10.3389/fnins.2023.1152959. PMID: 37694118; PMCID: PMC10491019.
3. Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De MoerlooseB, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K,Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, VoraA, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood AcuteLymphoblastic Leukemia Working Group. Outcomes of Childhood NoninfantAcute Lymphoblastic Leukemia With 11q23/ KMT2A Rearrangementsin a Modern Therapy Era: A Retrospective International Study. J ClinOncol. 2023 Mar 1;41(7):1404-1422. doi: 10.1200/JCO.22.01297. Epub 2022Oct 18. PMID: 36256911; PMCID: PMC9995095.
4. Chida-Nagai A, Masaki N, Maeda K, Sasaki K, Sato H, Muneuchi J, OchiaiY, Murayama H, Tahara M, Shiono A, Shinozuka A, Kono F, Machida D,Toyooka S, Sugimoto S, Nakamura K, Akagi S, Kondo M, Kasahara S, KotaniY, Koizumi J, Oda K, Harada M, Nakajima D, Murata A, Nagata H, YatsunamiK, Kobayashi T, Matsunaga Y, Inoue T, Yamagishi H, Nakagawa N, Ohtani K,Yamamoto M, Ito Y, Hokosaki T, Kuwahara Y, Masutani S, Nomura K, Wada T,Sawada H, Abiko M, Takahashi T, Ishikawa Y, Okada S, Naitoh A, Toda T,Ando T, Masuzawa A, Hoshino S, Kawada M, Nomura Y, Ueno K, Ohashi N,Tachibana T, Cao Y, Ueda H, Yanagi S, Koide M, Mitsushita N, Higashi K,Minosaki Y, Hayashi T, Okamoto T, Kuraishi K, Ehara E, Ishida H,Horigome H, Murakami T, Takei K, Ishii T, Harada G, Hirata Y, Maeda J,Tatebe S, Ota C, Hayabuchi Y, Sakazaki H, Sasaki T, Hirono K, Suzuki S,Yasuda M, Takeda A, Sawai M, Miyaji K, Kitagawa A, Nakai Y, Kakimoto N,Agematsu K, Manabe A, Saiki Y. Use of the index of pulmonary vasculardisease for predicting long-term outcome of pulmonary arterialhypertension associated with congenital heart disease. Front CardiovascMed. 2023 Sep 4;10:1212882. doi: 10.3389/fcvm.2023.1212882. Erratum in:Front Cardiovasc Med. 2024 Feb 01;11:1369831. PMID: 37731527; PMCID:PMC10507182.
5. Chida-Nagai A, Tonoki H, Makita N, Ishiyama H, Ihara M, Maruo Y,Tsujioka T, Sasaki D, Izumi G, Yamazawa H, Kato N, Ito M, Fujimura M,Sasaki O, Takeda A. A Noonan-like pediatric patient with a de novo CBLpathogenic variant and an RNF213 polymorphism p.R4810K presenting withcardiopulmonary arrest due to left main coronary artery ostial atresia.Am J Med Genet A. 2023 Dec;191(12):2837-2842. doi:10.1002/ajmg.a.63370. Epub 2023 Aug 9. PMID: 37554039.
6. Dong G, Adak S, Spyropoulos G, Zhang Q, Feng C, Yin L, Speck SL, ShyrZ, Morikawa S, Kitamura RA, Kathayat RS, Dickinson BC, Ng XW, PistonDW, Urano F, Remedi MS, Wei X, Semenkovich CF. Palmitoylation couplesinsulin hypersecretion with β cell failure in diabetes. Cell Metab.2023 Feb 7;35(2):332-344.e7. doi: 10.1016/j.cmet.2022.12.012. Epub 2023Jan 11. PMID: 36634673; PMCID: PMC9908855.
7. Egawa K, Watanabe M, Shiraishi H, Sato D, Takahashi Y, Nishio S, FukudaA. Imbalanced expression of cation-chloride cotransporters as apotential therapeutic target in an Angelman syndrome mouse model. SciRep. 2023 Apr 17;13(1):5685. doi: 10.1038/s41598-023-32376-z. PMID:37069177; PMCID: PMC10110603.
8. Eguchi K, Yaguchi H, Nakakubo S, Nakajima M, Ueda Y, Egawa K, ShiraishiH, Yabe I. Video-based detection of epileptic spasms in West syndromeusing a deep neural network: A pilot case study. J Neurol Sci. 2023 Jun15;449:120671. doi: 10.1016/j.jns.2023.120671. Epub 2023 May 5. PMID:37167655.
9. Elitzur S, Vora A, Burkhardt B, Inaba H, Attarbaschi A, Baruchel A,Escherich G, Gibson B, Liu HC, Loh M, Moorman AV, Möricke A, Pieters R,Uyttebroeck A, Baird S, Bartram J, Barzilai-Birenboim S, Batra S,Ben-Harosh M, Bertrand Y, Buitenkamp T, Caldwell K, Drut R, GeerlinksAV, Gilad G, Grainger J, Haouy S, Heaney N, Huang M, Ingham D, KrenovaZ, Kuhlen M, Lehrnbecher T, Manabe A, Niggli F, Paris C, Revel-Vilk S,Rohrlich P, Sinno MG, Szczepanski T, Tamesberger M, Warrier R, Wolfl M,Nirel R, Izraeli S, Borkhardt A, Schmiegelow K. EBV-driven lymphoidneoplasms associated with pediatric ALL maintenance therapy. Blood.2023 Feb 16;141(7):743-755. doi: 10.1182/blood.2022016975. PMID:36332176.
10. Fujishige S, Ogawa Y, Aoyagi H, Okamoto T. M-type phospholipase A2receptor-associated membranous nephropathy in a patient withNoonan-like syndrome with loose anagen hair. Pediatr Int. 2023Jan-Dec;65(1):e15643. doi: 10.1111/ped.15643. PMID: 37817399.
11. Fukuyama M, Horie M, Kato K, Aoki H, Fujita S, Yoshida Y, Sakazaki H,Toda T, Ueno M, Izumi G, Momoi N, Muneuchi J, Makiyama T, Nakagawa Y,Ohno S. Calmodulinopathy in Japanese Children　- Their CardiacPhenotypes Are Severe and Show Early Onset in Fetal Life and Infancy.Circ J. 2023 Nov 24;87(12):1828-1835. doi: 10.1253/circj.CJ-23-0195.Epub 2023 Jun 28. PMID: 37380439.
12. Hagio K, Kikuchi J, Takada K, Tanabe H, Sugiyama M, Ohhara Y, Amano T,Yuki S, Komatsu Y, Osawa T, Hatanaka KC, Hatanaka Y, Mitamura T, YabeI, Matsuno Y, Manabe A, Sakurai A, Ishiguro A, Takahashi M, Yokouchi H,Naruse H, Mizukami Y, Dosaka-Akita H, Kinoshita I. Assessment for thetiming of comprehensive genomic profiling tests in patients withadvanced solid cancers. Cancer Sci. 2023 Aug;114(8):3385-3395. doi:10.1111/cas.15837. Epub 2023 May 19. PMID: 37208840; PMCID: PMC10394138.
13. Hara-Isono K, Matsubara K, Nakamura A, Sano S, Inoue T, Kawashima S,Fuke T, Yamazawa K, Fukami M, Ogata T, Kagami M. Risk assessment ofassisted reproductive technology and parental age at childbirth for thedevelopment of uniparental disomy-mediated imprinting disorders causedby aneuploid gametes. Clin Epigenetics. 2023 May 6;15(1):78. doi:10.1186/s13148-023-01494-w. PMID: 37147716; PMCID: PMC10163687.
14. Hayashida K, Garcia A, Moonga LC, Sugi T, Takuya K, Kawase M, Kodama F,Nagasaka A, Ishiguro N, Takada A, Kajihara M, Nao N, Shingai M, Kida H,Suzuki Y, Hall WW, Sawa H, Yamagishi J. Field-deployable multiplexdetection method of SARS-CoV-2 and influenza virus using loop-mediatedisothermal amplification and DNA chromatography. PLoS One. 2023 May16;18(5):e0285861. doi: 10.1371/journal.pone.0285861. PMID: 37192155;PMCID: PMC10187927.
15. Hoshino Y, Arai J, Cho K, Yukitake Y, Kajikawa D, Hinata A, Miura R.Diagnosis and management of neonatal respiratory distress syndrome inJapan: A national survey. Pediatr Neonatol. 2023 Jan;64(1):61-67. doi:10.1016/j.pedneo.2022.08.002. Epub 2022 Aug 28. PMID: 36089536.
16. Hosokawa C, Hotta K, Okamoto T, Cho Y, Hirose T, Iwahara N, Manabe A,Shinohara N. Prophylactic bilateral nephrectomy and preemptive kidneytransplantation for Denys-Drash syndrome prior to development of kidneyfailure. Pediatr Nephrol. 2024 Mar;39(3):905-909. doi:10.1007/s00467-023-06113-7. Epub 2023 Aug 12. PMID: 37572117.
17. Imai C, Sato A, Hiwatari M, Shimomura Y, Hori T, Suenobu S, Imamura T,Hara J, Hasegawa D, Takahashi H, Moriya K, Katayama S, Tomizawa D,Moritake H, Taga T, Horibe K, Koh K, Manabe A, Okamoto Y. Outcomesfollowing induction failure in Japanese children with acutelymphoblastic leukemia. Int J Hematol. 2023 Jul;118(1):99-106. doi:10.1007/s12185-023-03600-3. Epub 2023 Apr 10. PMID: 37037958.
18. Iwahata Y, Takae S, Iwahata H, Matsumoto K, Hirayama M, Takita J,Manabe A, Cho Y, Ikeda T, Maezawa T, Miyachi M, Keino D, Koizumi T,Mori T, Shimizu N, Woodruff TK, Suzuki N. Investigation of FertilityPreservation Education Videos for Pediatric Patients Based onInternational and Historical Survey. J Adolesc Young Adult Oncol. 2023Dec;12(6):835-842. doi: 10.1089/jayao.2022.0154. Epub 2023 May 8. PMID:37155199.
19. Iwasaki S, Sato R, Kagami K, Akizawa K, Hayasaka K, Fukumoto T, Taki K,Niinuma Y, Yamada T, Oyamada R, Watanabe T, Nakakubo S, Watanabe C,Teshima T, Ishiguro N. Breaking away from an endemic state ofmultidrug-resistant Pseudomonas aeruginosa by daily sinkdisinfection. Antimicrob Steward Healthc Epidemiol. 2023 Nov15;3(1):e209. doi: 10.1017/ash.2023.484. PMID: 38156227; PMCID:PMC10753494.
20. Izumi G, Takeda A, Okamoto T, Shida S, Matsuo H. A case oftachycardia-induced acute kidney injury by renal hypouricemia. JCardiol Cases. 2023 Nov 10;29(2):59-62. doi:10.1016/j.jccase.2023.10.009. PMID: 38362583; PMCID: PMC10865112.
21. Kagami K, Ishiguro N, Iwasaki S, Usami T, Fukumoto T, Hayasaka K,Oyamada R, Watanabe T, Nakakubo S, Niinuma Y, Hagino T, Abe Y, FujimotoI, Maekawa H, Fujibayashi R, Fuke S, Asahi K, Ota S, Nagakura T, OkuboT, Asanuma H, Ito T, Okano S, Komatsu E, Sasaki K, Hashimoto K, WashiyaK, Kato Y, Kusumi K, Asai Y, Saito Y, Sakai Y, Sakurada M, Sakimoto Y,Ichikawa Y, Kinebuchi T, Kondo D, Kanno S, Kobayashi M, Hirabayashi K,Saitou S, Saito K, Ebina Y, Koshizaki Y, Chiba M, Yasuda A, Sato T,Togashi A, Abe T, Fujita T, Umehara K, Amishima M, Murakami N, Yagi T,Fujimoto S, Tajima T, Sugawara M, Takekuma Y. Correlation betweenantibiotic use and antibiotic resistance: A multicenter study using theJapan Surveillance for Infection Prevention and Healthcare Epidemiology(J-SIPHE) system in Hokkaido, Japan. Am J Infect Control. 2023Feb;51(2):163-171. doi: 10.1016/j.ajic.2022.05.025. Epub 2022 Jun 5.PMID: 35671846.
22. Kagami K, Ishiguro N, Iwasaki S, Taki K, Fukumoto T, Hayasaka K,Oyamada R, Watanabe T, Nakakubo S, Niinuma Y, Sugawara M, Takekuma Y.Correlation between antibiotic use and resistance of gram-negativebacteria at a university hospital in Japan from 2013 to 2021: a studyusing the Japan Surveillance for Infection Prevention and HealthcareEpidemiology (J-SIPHE) system. Eur J Hosp Pharm. 2023 Jul12:ejhpharm-2023-003797. doi: 10.1136/ejhpharm-2023-003797. Epub aheadof print. PMID: 37438092.
23. Kagami K, Kitajima M, Takahashi H, Teshima T, Ishiguro N. Associationof wastewater SARS-CoV-2 load with confirmed COVID-19 cases at auniversity hospital in Sapporo, Japan during the period from February2021 to February 2023. Sci Total Environ. 2023 Nov 15;899:165457. doi:10.1016/j.scitotenv.2023.165457. Epub 2023 Jul 25. PMID: 37499823.
24. Kagami K, Oyamada R, Watanabe T, Nakakubo S, Hayashi T, Iwasaki S,Fukumoto T, Usami T, Hayasaka K, Fujisawa S, Watanabe C, Nishida M,Teshima T, Niinuma Y, Yokota I, Takekuma Y, Sugawara M, Ishiguro N.Factors associated with household transmission of SARS-CoV-2 omicronvariant to health care workers: A retrospective cohort study. Int JNurs Pract. 2023 Oct;29(5):e13195. doi: 10.1111/ijn.13195. Epub 2023Aug 24. PMID: 37621085.
25. Kawaguchi K, Umeda K, Miyamoto S, Yoshida N, Yabe H, Koike T, KajiwaraM, Kawaguchi H, Takahashi Y, Ishimura M, Sakaguchi H, Hama A, Cho Y,Sato M, Kato K, Sato A, Kato K, Tabuchi K, Atsuta Y, Imai K.Graft-versus-host disease-free, relapse-free, second transplant-freesurvival in allogeneic hematopoietic cell transplantation for geneticdisorders. Bone Marrow Transplant. 2023 May;58(5):600-602. doi:10.1038/s41409-023-01937-1. Epub 2023 Feb 16. PMID: 36797422.
26. Kenri T, Yamazaki T, Ohya H, Jinnai M, Oda Y, Asai S, Sato R, IshiguroN, Oishi T, Horino A, Fujii H, Hashimoto T, Nakajima H, Shibayama K.Genotyping of Mycoplasma pneumoniae strains isolated in Japanduring 2019 and 2020: spread of p1 gene type 2c and 2j variantstrains. Front Microbiol. 2023 Jun 19;14:1202357. doi:10.3389/fmicb.2023.1202357. PMID: 37405159; PMCID: PMC10316025.
27. Kudo H, Suzuki R, Kondo A, Nozu K, Nakamura Y, Mikami H, Soma J, NakayaI. Association of Familial Fanconi Syndrome with a Novel GATM Variant.Tohoku J Exp Med. 2023 Aug 23;260(4):337-340. doi:10.1620/tjem.2023.J046. Epub 2023 Jun 8. PMID: 37286521.
28. Maezawa T, Suzuki N, Takeuchi H, Nishioka M, Hidaka M, Manabe A, KogaY, Kawaguchi H, Sasahara Y, Tachibana M, Iwamoto S, Horie A, HiramatsuH, Kato M, Harada M, Yuza Y, Hirayama M, Takita J, Ikeda T, MatsumotoK. Challenges to Widespread Use of Fertility Preservation Facilitiesfor Pediatric Cancer Patients in Japan. J Adolesc Young Adult Oncol.2023 Aug 3. doi: 10.1089/jayao.2023.0059. Epub ahead of print. PMID:37535825.
29. Maruo Y, Saito Y, Nishino I, Takeda A. Successful treatment of frequentpremature ventricular contractions and non-sustained ventriculartachycardia with verapamil and flecainide in RYR1-relatedmyopathy: a case report. Eur Heart J Case Rep. 2023 Oct13;7(10):ytad509. doi: 10.1093/ehjcr/ytad509. PMID: 37881357; PMCID:PMC10597318.
30. Miura K, Hattori M, Iwano M, Inoue E, Gotoh Y, Okamoto T, Nishiyama K,Hirano D, Nishimura K, Narita I. Depression and health-related qualityof life in adolescents and young adults with childhood-onset end-stagekidney disease: a multicenter study in Japan. Clin Exp Nephrol. 2023May;27(5):473-479. doi: 10.1007/s10157-023-02330-4. Epub 2023 Feb 25.PMID: 36840901.
31. Miura K, Hattori M, Iwano M, Okamoto T, Hamasaki Y, Gotoh Y, NishiyamaK, Fujinaga S, Hisano M, Hirano D, Narita I. Medical and psychosocialoutcomes in adolescents and young adults with childhood-onset end-stagekidney disease: a multicenter study in Japan. Clin Exp Nephrol. 2023May;27(5):454-464. doi: 10.1007/s10157-023-02327-z. Epub 2023 Feb 18.PMID: 36808382.
32. Nagasaki K, Minamitani K, Nakamura A, Kobayashi H, Numakura C, Itoh M,Mushimoto Y, Fujikura K, Fukushi M, Tajima T. Guidelines for NewbornScreening of Congenital Hypothyroidism (2021 Revision). Clin PediatrEndocrinol. 2023;32(1):26-51. doi: 10.1297/cpe.2022-0063. Epub 2022 Dec4. PMID: 36761493; PMCID: PMC9887297.
33. Nakakubo S, Hiramatsu Y, Goto T, Kimura S, Narugami M, Nakajima M, UedaY, Shiraishi H, Manabe A, Sharmin D, Cook JM, Egawa K. Therapeuticeffects of KRM-II-81, positive allosteric modulator for α2/3 subunitcontaining GABA_Areceptors, in a mouse model of Dravetsyndrome. Front Pharmacol. 2023 Oct 2;14:1273633. doi:10.3389/fphar.2023.1273633. PMID: 37849734; PMCID: PMC10577232.
34. Nakamura Y, Kobayashi S, Cho K, Itoh S, Miyashita C, Yamaguchi T, IwataH, Tamura N, Saijo Y, Ito Y, Seto Y, Honjo R, Ando A, Furuse Y, ManabeA, Kishi R; Japan Environment and Children’s Study (JECS) Group.Prenatal metal concentrations and physical abnormalities in the JapanEnvironment and Children's Study. Pediatr Res. 2023 Oct 19. doi:10.1038/s41390-023-02851-4. Epub ahead of print. Erratum in: PediatrRes. 2024 Mar 8;: PMID: 37857850.
35. Nishimura A, Yokoyama K, Naruto T, Yamagishi C, Imamura T, Nakazono H,Kimura S, Ito M, Sagisaka M, Tanaka Y, Piao J, Namikawa Y, YanagimachiM, Isoda T, Kanai A, Matsui H, Isobe T, Sato-Otsubo A, Higuchi N,Takada A, Okuno H, Saito S, Karakawa S, Kobayashi S, Hasegawa D,Fujisaki H, Hasegawa D, Koike K, Koike T, Rai S, Umeda K, Sano H,Sekinaka Y, Ogawa A, Kinoshita A, Shiba N, Miki M, Kimura F, NakayamaH, Nakazawa Y, Taga T, Taki T, Adachi S, Manabe A, Koh K, Ishida Y,Takita J, Ishikawa F, Goto H, Morio T, Mizutani S, Tojo A, Takagi M.Myeloid/natural killer (NK) cell precursor acute leukemia as a distinctleukemia type. Sci Adv. 2023 Dec 15;9(50):eadj4407. doi:10.1126/sciadv.adj4407. Epub 2023 Dec 13. PMID: 38091391.
36. Ohki K, Butler ER, Kiyokawa N, Hirabayashi S, Bergmann AK, Möricke A,Boer JM, Cavé H, Cazzaniga G, Yeoh AEJ, Sanada M, Imamura T, Inaba H,Mullighan CG, Loh ML, Norén-Nyström U, Shih LY, Zaliova M, Pui CH, HaasOA, Harrison CJ, Moorman AV, Manabe A. Clinical characteristics andoutcomes of B-cell precursor ALL with MEF2D rearrangements: aretrospective study by the Ponte di Legno Childhood ALL Working Group.Leukemia. 2023 Jan;37(1):212-216. doi: 10.1038/s41375-022-01737-4. Epub2022 Oct 29. PMID: 36309560; PMCID: PMC9883149.
37. Okada E, Aoto Y, Horinouchi T, Yamamura T, Ichikawa Y, Tanaka Y, UedaC, Kitakado H, Kondo A, Sakakibara N, Suzuki R, Usui J, Yamagata K,Iijima K, Nozu K. Aberrant splicing caused by exonic single nucleotidevariants positioned 2nd or 3rd to the last nucleotide in the COL4A5gene. Clin Exp Nephrol. 2023 Mar;27(3):218-226. doi:10.1007/s10157-022-02294-x. Epub 2022 Nov 12. PMID: 36371577; PMCID:PMC9950164.
38. Okada E, Horinouchi T, Yamamura T, Aoto Y, Suzuki R, Ichikawa Y, TanakaY, Masuda C, Kitakado H, Kondo A, Sakakibara N, Ishiko S, Nagano C,Ishimori S, Usui J, Yamagata K, Matsuo M, Nozu K. All reportednon-canonical splice site variants in GLA cause aberrant splicing. ClinExp Nephrol. 2023 Sep;27(9):737-746. doi: 10.1007/s10157-023-02361-x.Epub 2023 May 31. PMID: 37254000; PMCID: PMC10432374.
39. Onodera M, Uchiyama T, Ariga T, Yamada M, Miyamura T, Arizono H, MorioT. Safety and efficacy of elapegademase in patients with adenosinedeaminase deficiency: A multicenter, open-label, single-arm, phase 3,and postmarketing clinical study. Immun Inflamm Dis. 2023Jul;11(7):e917. doi: 10.1002/iid3.917. PMID: 37506145; PMCID:PMC10367445.
40. Ozono S, Sakashita K, Yoshida N, Kakuda H, Watanabe K, Maeda M, IshidaY, Manabe A, Taga T, Muramatsu H. A nationwide survey of late effectsin survivors of juvenile myelomonocytic leukemia in Japan. PediatrBlood Cancer. 2023 Feb;70(2):e30126. doi: 10.1002/pbc.30126. Epub 2022Dec 10. PMID: 36495260.
41. Sakashita K, Yoshida N, Muramatsu H, Ohtsuka Y, Watanabe K, Yabe M,Kakuda H, Honda Y, Watanabe T, Haba M, Ohmori S, Matsuda K, Yuza Y,Saito A, Horibe K, Adachi S, Manabe A. Allogeneic Hematopoietic CellTransplantation for Juvenile Myelomonocytic Leukemia with a Busulfan,Fludarabine, and Melphalan Regimen: JPLSG JMML-11. Transplant CellTher. 2024 Jan;30(1):105.e1-105.e10. doi: 10.1016/j.jtct.2023.10.002.Epub 2023 Oct 7. PMID: 37806448.
42. Sato A, Hatta Y, Imai C, Oshima K, Okamoto Y, Deguchi T, Hashii Y,Fukushima T, Hori T, Kiyokawa N, Kato M, Saito S, Anami K, Sakamoto T,Kosaka Y, Suenobu S, Imamura T, Kada A, Saito AM, Manabe A, Kiyoi H,Matsumura I, Koh K, Watanabe A, Miyazaki Y, Horibe K. Nelarabine,intensive L-asparaginase, and protracted intrathecal therapy for newlydiagnosed T-cell acute lymphoblastic leukaemia in children and youngadults (ALL-T11): a nationwide, multicenter, phase 2 trial includingrandomisation in the very high-risk group. Lancet Haematol. 2023Jun;10(6):e419-e432. doi: 10.1016/S2352-3026(23)00072-8. Epub 2023 May8. Erratum in: Lancet Haematol. 2023 Jun;10(6):e399. PMID: 37167992.
43. Sato H, Inoue Y, Kawashima Y, Konno R, Ohara O, Kuwana M, Kobayashi N,Takezaki S, Akioka S. In-depth proteomic analysis of juveniledermatomyositis serum reveals protein expression associated withmuscle-specific autoantibodies. Rheumatology (Oxford). 2023 Oct3;62(10):3501-3506. doi: 10.1093/rheumatology/kead165. PMID: 37052527.
44. Sato I, Takeda A. Long-term survival case with severe infantile Marfansyndrome: A case report. Pediatr Int. 2023 Jan-Dec;65(1):e15571. doi:10.1111/ped.15571. PMID: 37459280.
45. Shiraishi H, Egawa K, Murakami K, Nakajima M, Ueda Y, Nakakubo S,Narugami M, Kimura S, Goto T, Hiramatsu Y, Murakami M. Transcutaneousauricular vagus nerve stimulation therapy in patients with cognitivelypreserved structural focal epilepsy: A case series report. Brain Dev.2024 Jan;46(1):49-56. doi: 10.1016/j.braindev.2023.08.007. Epub 2023 Aug30. PMID: 37657962.
46. Shiraishi H, Teramoto T, Yokoshiki S, Tohyama J, Ueda Y, Egawa K, SatoN, Manabe A, Kato M. Efficacy of sirolimus for epileptic seizures inchildhood associated with focal cortical dysplasia type II. Brain Dev.2023 Jun;45(6):343-347. doi: 10.1016/j.braindev.2023.02.005. Epub 2023Mar 2. PMID: 36870920.
47. Suzuki R, Sakakibara N, Ichikawa Y, Kitakado H, Ueda C, Tanaka Y, OkadaE, Kondo A, Ishiko S, Ishimori S, Nagano C, Yamamura T, Horinouchi T,Okamoto T, Nozu K. Systematic Review of Clinical Characteristics andGenotype-Phenotype Correlation in LAMB2-Associated Disease.Kidney Int Rep. 2023 Jul 4;8(9):1811-1821. doi:10.1016/j.ekir.2023.06.019. PMID: 37705905; PMCID: PMC10496080.
48. Takeda A, Ueki M, Abe J, Maeta K, Horiguchi T, Yamazawa H, Izumi G,Chida-Nagai A, Sasaki D, Tsujioka T, Sato I, Shiraishi M, Matsuo M. Acase of infantile Barth syndrome with severe heart failure: Importanceof splicing variants in the TAZ gene. Mol Genet Genomic Med. 2023Jul;11(7):e2190. doi: 10.1002/mgg3.2190. Epub 2023 Apr 25. PMID:37186429; PMCID: PMC10337275.
49. Ueda Y, Egawa K, Kawamura K, Ochi N, Goto T, Kimura S, Narugami M,Nakakubo S, Nakajima M, Manabe A, Shiraishi H. Nusinersen inducesdetectable changes in compound motor action potential response inspinal muscular atrophy type 1 patients with severe impairment of motorfunction. Brain Dev. 2024 Mar;46(3):149-153. doi:10.1016/j.braindev.2023.12.001. Epub 2023 Dec 15. PMID: 38103972.
50. Ueda Y, Furugen A, Kobayashi M, Sato Y, Ueda Y, Hayashi A, Goto T,Kimura S, Narugami M, Nakakubo S, Nakajima M, Egawa K, Okamoto T,Manabe A, Shiraishi H. Use of lacosamide for focal epilepsy in a childwith kidney failure undergoing peritoneal dialysis. Brain Dev. 2024Feb;46(2):114-117. doi: 10.1016/j.braindev.2023.10.003. Epub 2023 Oct31. PMID: 37914622.
51. Ueda Y, Okamoto T, Sato Y, Hayashi A, Takahashi T, Suzuki R, Aoyagi H,Ueno M, Kobayashi N, Uetake K, Nakanishi M, Ariga T, Manabe A. Changesin bone turnover markers after discontinuing long-term glucocorticoidadministration in children with idiopathic nephrotic syndrome: amulticenter retrospective observational study. Pediatr Nephrol. 2023Oct;38(10):3285-3296. doi: 10.1007/s00467-023-05966-2. Epub 2023 Apr 13.PMID: 37052692.
52. Ueki M, Sakamoto K, Nishioka N, Ohata H, Nobuta T, Takezaki S, ManabeA, Yamada M. Rheumatologic manifestations with elevated levels of IL-6,IL-17A, and IL-23 in a patient with scurvy. Mod Rheumatol Case Rep.2023 Jan 3;7(1):302-306. doi: 10.1093/mrcr/rxac059. PMID: 35942728.
53. Yamada M, Suzuki H, Miya F, Kosugiyama K, Ujiie T, Tonoki H, Kosaki K.Precise definition of the breakpoints of an apparently balancedtranslocation between chromosome 3q26 and chromosome 7q36: Role ofKMT2C disruption. Congenit Anom (Kyoto). 2023 Jul;63(4):121-124. doi:10.1111/cga.12514. Epub 2023 Mar 28. PMID: 36946065.
54. Yamaguchi A, Tazawa Y, Ueki M, Yamada M, Manabe A, Sugawara M, TakekumaY. Therapeutic Drug Monitoring of Oral Voriconazole in an Infant Lessthan Six Months of Age and Pharmacokinetics Changes Induced byDevelopment of CYP2C19 in the Growth Process: A Novel Case Report.Yakugaku Zasshi. 2023;143(6):545-549. doi: 10.1248/yakushi.23-00001.PMID: 37258188.
55. Yoshida M, Nakabayashi K, Yang W, Sato-Otsubo A, Tsujimoto SI,Ogata-Kawata H, Kawai T, Ishiwata K, Sakamoto M, Okamura K, Yoshida K,Shirai R, Osumi T, Kiyotani C, Shioda Y, Terashima K, Ishimaru S, YuzaY, Takagi M, Arakawa Y, Imamura T, Hasegawa D, Inoue A, Yoshioka T, ItoS, Tomizawa D, Koh K, Matsumoto K, Kiyokawa N, Ogawa S, Manabe A, NiwaA, Hata K, Yang JJ, Kato M. Prevalence of pathogenic variants incancer-predisposing genes in second cancer after childhood solidcancers. Cancer Med. 2023 May;12(10):11264-11273. doi:10.1002/cam4.5835. Epub 2023 Apr 6. PMID: 37021926; PMCID: PMC10242325.
56. Zhao J, Ueki M, Sawai S, Sugiyama M, Terashita Y, Hirabayashi S, Cho Y,Kobayashi R, Tanaka Y, Manabe A. The heterozygous NUDT15 variant is notassociated with the severity of 6-mercaptopurine-related side effectsin early intensification therapy for childhood acute lymphoblasticleukemia. EJC Paediatric Oncology, Volume 1, 100006.https://doi.org/10.1016/j.ejcped.2023.100006

論文（邦文）

1. 鈴木諒太、野津寛大: X染色体の不活化と遺伝性腎疾患. 腎と透析94(3): 460-465, 2023
2. 武田充人：ミトコンドリア病における全身麻酔と鎮静. 「ミトコンドリア病診療マニュアル2023」（診断と治療社,2023）
3. 武田充人：ミトコンドリア心筋症を中心にした代謝と病態の関連. 生体の科学「代謝」Vol.74 No.5, 2023
4. 武田充人：ミトコンドリア心筋症. 日本臨床　2023年11月号
5. 武田充人：デュシェンヌ型筋ジストロフィー（DMD)診療の最前線　合併症のケア「心筋症の管理」. Progress in medicine　2023年11月号
6. 武田充人: 救急外来で見つけて対応するー時間的余裕のない場合「心筋障害,心不全」.小児科ベストプラクティス　外来で見つける先天代謝異常症ーシマウマ診断の勧め（中山書店, 　2023）
7. 武田 充人、山澤 弘州、池田 善彦：CQ17 ミトコンドリア心筋症の診断の進め方は？.「ミトコンドリア病診療マニュアル2023」（診断と治療社,2023）
8. 武田 充人、岡崎 敦子：CQ16 ミトコンドリア心筋症の症状は？. 「ミトコンドリア病診療マニュアル2023」（診断と治療社,2023）
9. 武田 充人、岡崎 敦子：CQ15 ミトコンドリア心筋症とはどのような疾患ですか？.「ミトコンドリア病診療マニュアル2023」（診断と治療社,2023）
10. 菱村希：こどものことをもっと知ろう 低身長. LiSA Vol.30 No.12, 2023
11. 竹崎俊一郎：感染症の予防や注意点に関するQ＆A. 「若年性特発性関節炎患者支援の手引き」（羊土社, 2023）
12. 竹崎俊一郎：感染症の予防や注意点に関するQ&A.「若年性特発性関節炎患者支援の手引き」
13. 竹崎俊一郎：CQ7　小児喘息患者において、吸入ステロイド薬(ICS)で長期管理中にステップアップする際はICSの増量とICSに長時間作用性吸入β2刺激薬(LABA)を追加する方法(ICS/LABA)のどちらが有用か？.「小児気管支喘息治療・管理ガイドライン2023」
14. 竹崎俊一郎：CQ4　小児喘息患者の長期管理において、有症状時にのみ吸入ステロイド薬(ICS)を吸入（間欠吸入）することは有用か？.「小児気管支喘息治療・管理ガイドライン2023」
15. 竹崎俊一郎：CQ2　小児喘息思者の長期管理において、ダニアレルゲン特異的免疫療法は有用か？. 「小児気管支喘息治療・管理ガイドライン2023」
16. 竹崎俊一郎：CQ13　小児のウイルス感染による喘鳴の治療にロイコトリエン受容体拮抗薬(LTRA)は有用か？.「小児気管支喘息治療・管理ガイドライン2023」
17. 泉岳：CQ 20　ミトコンドリア心筋症に合併する不整脈とその治療は？. 「ミトコンドリア病診療マニュアル2023」（診断と治療社,2023）
18. 岡本孝之：病因・病態生理から読み解く腎・泌尿器疾患のすべて「TINU症候群（サルコイドーシス）」. 腎と透析 2023年95巻増刊号
19. 岡本孝之：エキスパートが教える小児の薬物治療「腎性尿崩症」.小児内科 2023年55巻増刊号
20. 永井礼子：肺高血圧症の遺伝学的背景に関する最近の話題. 日本小児循環器学会雑誌　2023; 39(2): 62‒68
21. 植田佑樹： CQ1 発作が遷延する場合の早期治療にはどのようなものがあるか.「小児てんかん重積状態・けいれん重積状態治療ガイドライン」（診断と治療社, 2023）
22. 真部淳：小児の骨髄異形成症候群. 血液専門医テキスト（改訂第4版）（日本血液学会編）、p459-462, 2023、南江堂（東京）
23. 真部淳：チーム医療における保育士の役割　–小児がんを例にとって–. 医療と保育 21:2-10, 2023
24. 齋藤昭彦、伊藤秀一、成田雅美、齋藤伸治、大賀正一、真部淳：新型コロナウイルス感染症による大学病院の面会・付き添い制限の現状と課題. 日児誌　127:1540-1545,2023
25. 真部淳：がん・白血病の病名告知をめぐる課題. 小児科 64:577-582,2023
26. 寺下友佳代、真部淳：移行期医療. がん・生殖医療 （柴原浩章編集、鈴木直企画）、p178-180, 2023、中外医学社（東京）
27. 真部淳、長谷川大輔、多賀崇、小島勢二：Congenital dyserythropoietic anemia　(CDA)　遺伝性骨髄不全症診療ガイドライン2023（日本小児血液・がん学会編）診断と治療社（東京）2023 p37-43, 2023
28. 平林真介、真部淳、大木健太郎、清河信敬：小児B前駆細胞性急性リンパ性白血病におけるZNF384再構成とMEF2D再構成の特徴. 臨床血液　64:633-638,2023
29. 三田村真太郎, 石川耕資, 長和俊, 古瀬優太, 中村雄一, 本庄遼太, 前田拓, 山本有平.低出生体重児の顔面に生じた乳児血管腫に対するプロプラノロール内服療法の2例. 形成外科 66巻11号　Page1336-1345(2023.11)
30. 小野夏実, 金子直哉, 中山加奈子, 菱村希, 山口健史, 森川俊太郎, 真部淳,中村明枝：高用量ステロイド吸入により医原性グルココルチコイド過剰および二次性副腎皮質機能不全をきたした女児例. 臨床小児医学 70(1-6):57-63, 2023

特許

特許　第7218897号, 出願番号　特願 2018-551676
心不全の治療及び/又は予防に用いるための心筋幹細胞の製造方法
（発明者　原島秀吉、山田勇磨、阿部二郎、武田充人）

令和4（2022）年度

2022年度研究費取得状況

論文・著書など

論文（欧文）

1. Takizawa K, Ueda K, Sekiguchi M, Nakano E, Kajiho Y, Kanda S, Miura K, Hattori M, Hashimoto J, Hamasaki Y, Hisano M, Omori T, Okamoto T, Kitayama H, Fujita N, Kuramochi H, Ichiki T, Oka A, Harita Y: Urinary extracellular vesicles signature for diagnosis of kidney disease. iScience. 25(11): 105416, 2022
2. Nagano C, Hara S, Yoshikawa N, Takeda A, Gotoh Y, Hamada R, Matsuoka K, Yamamoto M, Fijinaga S, Sakuraya K, Kamei K, Hamasaki Y, Oguchi H, Araki Y, Ogawa Y, Okamoto T, Ito S, Tanaka S, Kaito H, Aoto Y, Ishiko S, Rossanti R, Sakakibara N, Horinouchi T, Yamamura T, Nagase H, Iijima K, Nozu K: Clinical, pathological and genetic characteristics in patients with focal segmental glomerulosclerosis. Kidney360 3(8):　1384-1393, 2022
3. Hayashi A, Okamoto T, Nio-Kobayashi J, Iwahara N, Suzuki R, Ueda Y, Takahashi T, Sato Y, Iwanaga T, Hotta K: CD44 as a pathological marker for early detection of calcineurin inhibitor-induced nephrotoxicity after kidney transplantation. Biomed Res 43(5): 181-186, 2022
4. Takahashi T, Okamoto T, Yokota I, Sato Y, Hayashi A, Ueda Y, Aoyagi H, Ueno M, Kobayashi N, Uetake K, Nakanishi M, Ariga T. The effect of rituximab on the quality of life of children with refractory nephrotic syndrome. Pediatr Int 64(1), 2022
5. Iijima K, Sako M, Oba M, Tanaka S, Hamada R, Sakai T, Ohwada Y, Ninchoji T, Yamamura T, Machida H, Shima Y, Tanaka R, Kaito H, Araki Y, Morohashi T, Kumagai N, Gotoh Y, Ikezumi Y, Kubota T, Kamei K, Fujita N, Ohtsuka Y, Okamoto T, Yamada T, Tanaka E, Shimizu M, Horinochi T, Konishi A, Omori T, Nakanishi K, Ishikura K, Ito S, Nakamura H, Nozu K; Japanese Study Group of Kidney Disease in Children. Mycophenolate Mofetil after Rituximab for Childhood-Onset Complicated Frequently-Relapsing or Steroid-Dependent Nephrotic Syndrome. J Am Soc Nephrol. 33(2):401-419, 2022
6. Ueda Y, Okamoto T, Sato Y, Hayashi A, Takahashi T, Kamada K, Honda S, Hotta K. Kidney transplantation after peritoneal dialysis-associated peritonitis and abdominal abscesses caused by Mycobacterium massiliense: lesson for the clinical nephrologist. J Nephrol 35(7), 2022
7. Suzuki R, Hayashi A, Endo M, Ueda Y, Takahashi T, Sato Y, Okamoto T. Cooccurrence of Alport syndrome and poststreptococcal acute glomerulonephritis with improvement after steroid administration. CEN Case Rep 11(4), 2022
8. Morikawa S, Urano F: The Role of ER Stress in Diabetes: Exploring Pathological Mechanisms Using Wolfram Syndrome. Int J Mol Sci 24(1): 230, 2022
9. Morikawa S, Blacher, Onwumere C, Urano F: Loss of function of WFS1 causes ER stress-mediated inflammation in pancreatic beta-cells. Front Endocrinol 13, 2022
10. Batjargal K, Tajima T, Fujita-Jimbo E, Yamaguchi T, Nakamura A, Yamagata T: Functional analysis of PAX8 variants identified in patients with congenital hypothyroidism in situ. Clin Pediatr Endocrinol 31(4): 234-241, 2022
11. Kobayashi S, Itoh S, Miyashita C, Ait Bamai Y, Yamaguchi T, Masuda H, Itoh M, Yamazaki K, Tamura N, Hanley SJB, Ikeda-Araki A, Saijo Y, Ito Y, Iwai-Shimada M, Yamazaki S, Kamijima M, Kishi R; Japan Environment, Children's Study JECS Group: Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children's study using the ASQ-3 questionnaire: A prospective birth cohort. Environ Int 168, 2022
12. Itoh S, Yamazaki K, Suyama S, Ikeda-Araki A, Miyashita C, Ait Bamai Y, Kobayashi S, Masuda H, Yamaguchi T, Goudarzi H, Okada E, Kashino I, Saito T, Kishi R: The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study. Environ Int 159, 2022
13. Ueda Y, Fujishige S, Goto T, Kimura S, Namatame N, Narugami M, Nakakubo S, Nakajima M, Egawa K, Kaneko N, Nakayama K, Hishimura N, Yamaguchi T, Nakamura A, Shiraishi H: Adrenal function during long‐term ACTH therapy for patients with developmental and epileptic encephalopathy. Epilepsia Open 7: 194-200, 2022
14. Kawashima S, Yuno A, Sano S, Nakamura A, Ishiwata K, Kawasaki T, Hosomichi K, Nakabayashi K, Akutsu H, Saitsu H, Fukami M, Usui T, Ogata T, Kagami M: Familial Pseudohypoparathyroidism Type IB Associated with an SVA Retrotransposon Insertion in the GNAS Locus. J Bone Miner Res37(10):1850-1859, 2022
15. Fuke T, Nakamura A, Inoue T, Kawashima S, Hara-Isono K, Matsubara K, Sano S, Yamazawa K, Fukami M, Ogata T, Kagami M: Frequency and clinical characteristics of distinct etiologies in patients with Silver-Russell syndrome diagnosed based on the Netchine-Harbison clinical scoring system. J Hum Genet 67(10): 607-611, 2022
16. Hara-Isono K, Nakamura A, Fuke T, Inoue T, Kawashima S, Matsubara K, Sano S, Yamazawa K, Fukami M, Ogata T, Kagami M: Pathogenic Copy Number and Sequence Variants in Children Born SGA With Short Stature Without Imprinting Disorders. J Clin Endocrinol Metab 107(8): e3121–e3133, 2022
17. Kobayashi I, Shimomura M, Ueki M, Takezaki S, Okura Y, Nawate M, Yamada M, Takahashi Y, Ariga T: Development of Graves' disease during drug-free remission of juvenile dermatomyositis. Mod Rheumatol Case Rep6(1): 55-58, 2022
18. Shimaa Abdrabou, Nariaki Toita, Shin Ichihara, Yusuke Tozawa, Michiko Takahashi, Shin-ichi Fujiwara, Toshifumi Ashida, Osamu Ohara, Tadashi Ariga, Atsushi Manabe, Mutsuko Konno, Masafumi Yamada. Absent XIAP expression in T cell blasts and causal XIAP mutations including non-coding deletion. Pediatr Int. 64-(1):e14892. 2022
19. Zineb Sbihi, Kay Tanita, Camille Bachelet, Christine Bole, Fabienne Jabot-Hanin, Frederic Tores, Marc Le Loch, Radi Khodr, Akihiro Hoshino, Christelle Lenoir, Matias Oleastro, Mariana Villa, Lucia Spossito.., Takashi Taga, Shimaa Abdrabou, Takeshi Isoda, Masafumi Yamada, Alejandro Palma, Hirokazu Kanegane, Sylvain Latour. Identification of germline non-coding deletions in XIAP gene causing XIAP deficiency reveals a key promoter sequence. J Clin Immunol.42, 559–571. 2022
20. Kuroko Y, Yoshihara H, Hosoya Y, Manabe A, Hasegawa D: Intrathecal therapy in acute lymphoblastic leukemia case with spinal deformity. Pediatr Int 64: e14845, 2022
21. Hama A, Hasegawa D, Manabe A, Nozawa K, Narita A, Muramatsu H, Kosaka Y, Kobayashi M, Koh K, Takahashi Y, Watanabe K, Ohara A, Ito M, Kojima S: Prospective validation of the provisional entity of refractory cytopenia of childhood, proposed by the World Health Organization. Br J Haematol 196: 1031-1039, 2022
22. Honda Y, Muramatsu H, Nanjo Y, Hirabayashi S, Meguro T, Yoshida N, Kakuda H, Ozono S, Wakamatsu M, Moritake H, Yasui M, Sano H, Manabe A, Sakashita K: A retrospective analysis of azacitidine treatment for juvenile myelomonocytic leukemia. Int J Hematol 115: 263-268, 2022
23. Buchmann S, Schrappe M, Baruchel A, Biondi A, Borowitz M, Campbell M, Cario G, Cazzaniga G, Escherich G, Harrison C, Heyman M, Hunger S, Kiss C, Liu HC, Locatelli F, Loh M, Manabe A, Mann G, Pieters R, Pui CH, Rives S, Schmiegelow K, Silverman L, Stary J, Vora A, Brown P: Remission, treatment failure, and relapse in pediatric ALL: An international consensus of the Ponte-di-Legno Consortium. Blood 139: 1785-1793, 2022
24. Hasegawa M, Sugiyama M, Terashita Y, Cho Y, Manabe A: Hepatoblastoma with bone/bone marrow metastasis in Li-Fraumeni syndrome patient. Pediatr Int 64(1), 2022
25. Tanaka Y, Urayama KY, Mori M, Arakawa Y, Hasegawa D, Noguchi Y, Yanagimachi M, Keino D, Ota S, Akahane K, Inukai T, Hangai M, Kawaguchi T, Takagi M, Koh K, Matsuda F, Manabe A: Prominence of NUDT15 genetic variation associated with 6-mercaptopurine tolerance in a genome-wide association study of Japanese children with acute lymphoblastic leukemia. Br J Haematol 199: 260-269, 2022
26. Yamaguchi S, Okamoto M, Ishi Y, Sawaya R, Motegi H, Sugiyama M, Harada T, Fujima N, Mori T, Hashimoto T, Takakuwa E, Manabe A, Kudo K, Aoyama H, Fujimura M. Long-term consequences of residual lesions after chemoradiotherapy in patients with germinoma at onset. J Neurosurg Pediatr, 30(5), 517-524. 2022
27. Yoshimoto-Suzuki YY, Hasegawa D, Hosoya Y, Saito G, Nagase K, Gunji M, Kobayashi K, Ishida Y, Manabe A, Ozawa M: Significance of active screening for detection of health problems in childhood cancer survivors. Front Pediatr 10: 947646, 2022
28. Kobayashi K, Ishida Y, Gunji M, Nagase K,Yoshimoto-Suzuki Y, Hosoya Y, Hasegawa D, Manabe A, Ohde S, Ozawa M: Factors related to employment in childhood cancer survivors in Japan: a preliminary study. Front Pediatr 10: 961935, 2022
29. Mitamura M, Kase S, Hirooka K, Endo H, Ito Y, Cho Y, Ishida S: Alterations of choroidal circulation and vascular morphology in a patient with chronic myeloid leukemia before and after chemotherapy. BMC Ophthalmol 22(1): 160, 2022
30. Nishida M, Sugita J, Iwai T, Sato M, Kudo Y, Omotehara S, Horie T, Sakano R, Hasegawa Y, Yasumoto A, Cho Y, Teshima T: Ultrasonographic scoring system of late-onset sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation. Bone Marrow Transplant 57(8): 1338-1340. 2022
31. Suekane A, Ichikawa T, Saito Y, Nakahata S, Morishita K: The CGRP Receptor Antagonist MK0974 Induces EVI1high AML Cell Apoptosis by Disrupting ERK Signaling. Anticancer Res 42: 4743-4752, 2022
32. Tanida R, Tsubouchi H, Yanagi S, Saito Y, Toshinai K, Miyazaki T, Takamura T, Nakazato M: GHS-R1a deficiency mitigates lipopolysaccharide-induced lung injury in mice via the downregulation of macrophage activity. Biochem Biophys Res Commun 589: 260-266, 2022
33. Kinoshita M, Yamada A, Saito Y, Kamimura S, Moritake H: Successful treatment with rituximab for autoimmune cytopenia after autologous hematopoietic stem cell transplantation. Pediatr int 64: e14975, 2022
34. Saito Y, Suwa Y, Kaneko Y, Tsujiwaki M, Odagawa Y: Kikuchi-Fujimoto disease following COVID-19 infection in a 7-year-old girl: a case report and literature review. Cureus 14: e26540, 2022
35. Norrish G, Cleary A, Field E, Cervi E, Boleti O, Ziółkowska L, Olivotto I, Khraiche D, Limongelli G, Anastasakis A, Weintraub R, Biagini E, Ragni L, Prendiville T, Duignan S, McLeod K, Ilina M, Fernandez A, Marrone C, Bökenkamp R, Baban A, Kubus P, Daubeney PEF, Sarquella-Brugada G, Cesar S, Klaassen S, Ojala TH, Bhole V, Medrano C, Uzun O, Brown E, Gran F, Sinagra G, Castro FJ, Stuart G, Yamazawa H, Barriales-Villa R, Garcia-Guereta L, Adwani S, Linter K, Bharucha T, Gonzales-Lopez E, Siles A, Rasmussen TB, Calcagnino M, Jones CB, De Wilde H, Kubo T, Felice T, Popoiu A, Mogensen J, Mathur S, Centeno F, Reinhardt Z, Schouvey S, Elliott PM, Kaski JP: Clinical Features and Natural History of Preadolescent Nonsyndromic Hypertrophic Cardiomyopathy. J Am Coll Cardiol 79(20): 1986-1997, 2022
36. Norrish G, Ding T, Field E, Cervi E, Ziółkowska L, Olivotto I, Khraiche D, Limongelli G, Anastasakis A, Weintraub R, Biagini E, Ragni L, Prendiville T, Duignan S, McLeod K, Ilina M, Fernández A, Marrone C, Bökenkamp R, Baban A, Kubus P, Daubeney PEF, Sarquella-Brugada G, Cesar S, Klaassen S, Ojala TH, Bhole V, Medrano C, Uzun O, Brown E, Gran F, Sinagra G, Castro FJ, Stuart G, Vignati G, Yamazawa H, Barriales-Villa R, Garcia-Guereta L, Adwani S, Linter K, Bharucha T, Garcia-Pavia P, Siles A, Rasmussen TB, Calcagnino M, Jones CB, De Wilde H, Kubo T, Felice T, Popoiu A, Mogensen J, Mathur S, Centeno F, Reinhardt Z, Schouvey S, O'Mahony C, Omar RZ, Elliott PM, Kaski JP: Relationship Between Maximal Left Ventricular Wall Thickness and Sudden Cardiac Death in Childhood Onset Hypertrophic Cardiomyopathy. Circ Arrhythm Electrophysiol 15(5): e010075, 2022
37. Yamazawa H, Takeda A, Izumi G, Komaki H, Nishino I: Sudden cardiac death prevention in an Emery-Dreifuss muscular dystrophy patient. Pediatr Int: e15204, 2022
38. Murakami T, Shiraishi M: What connects body height and flow-mediated vasodilation?. Hypertension Research 45(7): 1220, 2022
39. Murakami T, Shiraishi M: Pulse pressure amplification is one of the important factors evaluating peripheral blood pressure during exercise. Journal of Hypertension 40: 1245, 2022
40. Murakami T, Shiraishi M, Niwa K: Aortic root dilatation and aortic stiffness. Journal of Hypertension 40: 1431, 2022
41. Murakami T, Shiraishi M: The sex difference in the association of enhanced brachial-ankle pulse wave velocity and adverse cardiac remodeling; the possible background mechanism. Journal of Hypertension 40: 1432, 2022
42. Inai K, Inuzuka R, Ono H, Nii M, Ohtsuki S, Kurita Y, Takeda A, Hirono K, Takei K, Yasukouchi S, Yoshikawa T, Furutani Y, Shimada E, Shinohara T, Shinozaki T, Matsuyama Y, Senzaki H, Nakanishi T: Predictors of long-term mortality among perioperative survivors of Fontan operation. Eur Heart J 43(25): 2373-2384, 2022
43. Ohyama-Tamagake A, Kaneko K, Itami R, Nakano M, Namioka Y, Izumi R, Sato H, Suzuki H, Takeda A, Okazaki Y, Yatsuka Y, Abe T, Murayama K, Sugeno N, Misu T, Aoki M: Adult-onset Leigh Syndrome with a m.9176 T>C Mutation Manifested as Reversible Cerebral Vasoconstriction Syndrome. Intern Med, 2022 [online ahead of print].
44. Watanabe K, Maruo Y, Takeda A: Efficacy of cibenzoline for hypertrophic obstructive cardiomyopathy in paediatric patients with RAS/MAPK pathway syndromes. Cardiol Young: 1-3, 2022
45. Abe J, Honda M, Sasaki D, Taniguchi K, Izumi G, Furukawa T, Yamazawa H, Takei K, Takeda A: A geometrical pitfall of Area-Length method; -Is left ventricle volume evaluation of repaired Tetralogy of Fallot by angiocardiography accurate?. Heart Vessels 37(10): 1785-1791, 2022
46. Takahashi S, Segoe H, Kikuiri T, Maruo Y, Sato T, Watanabe Y, Jimei Z, Yoshimura Y, Ishiyama M, Takeda A, Yawaka Y, Shirakawa T: A rare case of multiple brain abscesses caused by apical periodontitis of deciduous teeth in congenital heart disease: a case report. BMC Oral Health 22(1): 261, 2022
47. Shimozawa H, Sato T, Osaka H, Takeda A, Miyauchi A, Omika N, Yada Y, Kono Y, Murayama K, Okazaki Y, Kishita Y, Yamagata T: A Case of Infantile Mitochondrial Cardiomyopathy Treated with a Combination of Low-Dose Propranolol and Cibenzoline for Left Ventricular Outflow Tract Stenosis. Int Heart J 63(5): 970-977, 2022
48. Chida-Nagai A, Tsujino I, Yakuwa S, Akagawa H, Tsujioka T, Taniguchi K, Sasaki O, Izumi G, Yamazawa H, Takeda A: A cardiac arrest case due to left coronary artery compression in congenital heart disease-associated pulmonary arterial hypertension. CJC Pediatric and Congenital Heart Disease, 2022 [online published]
49. Chida-Nagai A, Tsujioka T, Sasaki D, Izumi G, Yamazawa H, Takeda A: An Adolescent Patient With Idiopathic Pulmonary Arterial Hypertension Weaned Off Intravenous Epoprostenol Following Treatment With Selexipag: A Case Report. Front Pediatr, 2022
50. Chida-Nagai A,Sato H, Sato I, Shiraishi M, Sasaki D, Izumi G, Yamazawa H, Cho K, Manabe A, Takeda A: Risk factors for hospitalisation due to respiratory syncytial virus infection in children receiving prophylactic palivizumab. Eur J Pediatr 181(2): 539-547, 2022
51. Chiba Y, Izumi G,Takeda A: Atypical sites of twin atrioventricular nodes in a rare form of univentricular heart. Pacing Clin Electrophysiol 45(10): 1225-1228, 2022
52. Izumi G, Takeda A, Yamazawa H, Nagai A, Sasaki D, Sato I, Kato N, Tachibana T: Usefulness of Prolonged PR Interval to Predict Atrial Tachyarrhythmia Development Following Surgical Repair of Tetralogy of Fallot. IAm J Cardiol 184,127-132, 2022
53. Izumi G, Takeda A, Yamazawa H, Kato N, Kato H, Tachibana T, Sagae O, Yahagi R, Maeno M, Hoshino K, Saito H. Perioperative junctional ectopic tachycardia associated with congenital heart disease: risk factors and appropriate interventions. Heart Vessels 37: 1792-1800, 2022
54. Sasaki D, Abe J, Takeda A, Harashima H and Yamada Y: Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect. Scientific Reports 12(1): 4344, 2022
55. Yamada K, Takahata M, Ito M, Nagahama K, Iwata A, Endo T, Sudo H, Ishiguro N, Iwasaki N: Risk factors of multidrug-resistant pyogenic spondylitis in thoraco-lumbar spine: A retrospective study of 122 cases. J Orthop Sci 27(1): 95-100, 2022
56. Oka K, Matsumoto A, Tetsuka N, Morioka H, Iguchi M, Ishiguro N, Nagamori T, Takahashi S, Saito N, Tokuda K, Igari H, Fujikura Y, Kato H, Kanai S, Kusama F, Iwasaki H, Furuhashi K, Baba H, Nagao M, Nakanishi M, Kasahara K, Kakeya H, Chikumi H, Ohge H, Azuma M, Tauchi H, Shimono N, Hamada Y, Takajo I, Nakata H, Kawamura H, Fujita J, Yagi T; Japan Infection Prevention and Control Conference for National and Public University Hospitals: Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan. J Glob Antimicrob Resist: 247-252., 2022
57. Norrish G, Qu C, Field E, Cervi E, Khraiche D, Klaassen S, Ojala TH, Sinagra G, Yamazawa H, Marrone C, Popoiu A, Centeno F, Schouvey S, Olivotto I, Day SM, Colan S, Rossano J, Wittekind SG, Saberi S, Russell M, Helms A, Ingles J, Semsarian C, Elliott PM, Ho CY, Omar RZ, Kaski JP: External validation of the HCM Risk-Kids model for predicting sudden cardiac death in childhood hypertrophic cardiomyopathy. Eur J Prev Cardiol 29(4): 678-686, 2022
58. Tsujioka T, Sasaki D, Takeda A, Harashima H, Yamada Y: Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells. Int J Mol Sci 23(1): 112, 2022
59. Yamazawa H,Takeda A, Izumi G: Challenges in the primary prevention of sudden cardiac death in hypertrophic cardiomyopathy in the young. Cardiol Young 32(1): 156-157, 2022
60. Kato M, Kada A, Shiraishi H, Tohyama J, Nakagawa E, Takahashi Y, Akiyama T, Kakita A, Miyake N, Fujita A, Saito AM, Inoue Y: Sirolimus for epileptic seizures associated with focal cortical dysplasia type II. Ann Clin Transl Neurol 9(2): 181-192, 2022
61. Inoue Y, Hamano SI, Hayashi M, Sakuma H, Hirose S, Ishii A, Honda R, Ikeda A, Imai K, Jin K, Kada A, Kakita A, Kato M, Kawai K, Kawakami T, Kobayashi K, Matsuishi T, Matsuo T, Nabatame S, Okamoto N, Ito S, Okumura A, Saito A, Shiraishi H, Shirozu H, Saito T, Sugano H, Takahashi Y, Yamamoto H, Fukuyama T, Kuki I: Burden of seizures and comorbidities in patients with epilepsy: a survey based on the tertiary hospital-based Epilepsy Syndrome Registry in Japan. Epileptic Disord 24(1): 82-94, 2022
62. Okanishi T, Fujii Y, Sakuma S, Shiraishi H, Motoi H, Yazaki K, Enoki H, Fujimoto A: Lacosamide monotherapy for the treatment of childhood epilepsy with centrotemporal spikes. Brain Dev 44(6): 380-385, 2022
63. Sueda K, Hashimoto R, Ueda T: Convergent validity of the developmental coordination disorder checklist using soft neurological signs. Brain Dev 44(1): 17-29, 2022

論文（邦文）

1. 長　和俊、西村千織、朴澤博之、橋本孝史、山本ルイス: 北海道における不規則なRSウイルス感染症流行パターンの解析. 小児科診療(0386-9806)85(11): 1477-1482, 2022.11
2. 印南裕貴、馬場志郎、中澤温子、大塚沙樹、武野　亨、吉永大介、松田浩一、赤木健太郎、平田拓也、井出雄二郎、池田　義、長　和俊、滝田順子: Ebstein病根治術後も呼吸不全が遷延し、間質性肺疾患の合併が判明した男児例. 小児科臨床(0021-518X)75(3): 431-437, 2022.06
3. 古瀬優太: 子ども虐待対応のための基礎知識と医療の役割(日本子ども虐待医学会推薦総説). 日本小児科学会雑誌(0001-6543)126(5): 769-782, 2022.05
4. 長　和俊: 胎児肺の成長・発達と出生後の呼吸の適応生理. with Neo 2022秋季増刊: 10-15, 2022.09
5. 古瀬優太: 新生児の適応生理「呼吸」. with NEO(2434-4540)35(5): 674-685, 2022.10
6. 長　和俊:「肺胞蛋白症診療ガイドライン2022」：「先天性肺胞蛋白症／遺伝性肺胞蛋白症（CPAP/HPAP）および肺サーファクタント関連遺伝子変異由来での病態、診断、治療、合併症、予後」https://www.jrs.or.jp/publication/file/pap2022.pdf
7. 外木秀文: 先天異常　病気が見えるVol 15. 小児科: 156-173, 2022, メディックメディア 東京
8. 竹内千仙、井手友美、植田紀美子、大石　智、北畠康司、黒柳裕一、小松知子、玉井　浩、外木秀文、橋本洋之: ダウン症成人診療ガイドライン翻訳プロジェクト. 日本語版　成人期ダウン症診療ガイドライン　Web公開　日本ダウン症学会, 2022
9. 長谷河昌孝、長　祐子、大久保淳、寺下友佳代、杉山未奈子、井口晶裕、河北一誠、荒　桃子、本多昌平、若林健人、高桑恵美、外木秀文、真部　淳: ウィリアムズ症候群の男児に発症したバーキットリンパ腫. 小児血液がん学会雑誌59(3): 292–295, 2022
10. 大園秀一、石田也寸志、前田美穂、大植孝治、上別府圭子、清谷知賀子、竹之内直子、長　祐子、湯坐有希、家原知子、宮村能子、檜山英三、松本公一、大賀正一 (日本小児血液・がん学会長期フォローアップ・移行期医療委員会): 小児期発症血液・腫瘍性疾患の成人への移行期支援に関する基本的姿勢(解説). 日本小児血液・がん学会雑誌(2187-011X)59(1): 58-65
11. 白石秀明: 脳波の読み方 -up to date 自然終息性（self-limited）てんかん: CLINICAL NEUROSCIENCE: 468-473, 中外医学社, 東京, 2022
12. 植田佑樹、白石秀明: 脳の形態異常. 周産期医学必修知識　第9版: 東京医学社, 東京, 2022
13. 石黒信久: 治療法の再整理とアップデートのために専門家による私の治療　ライム病. 日本医事新報 5143: 43-44 , 2022
14. 石黒信久、田村祐子: 【新型コロナとインフルエンザ　同時流行に備えるために再確認しておきたいこと】感染防御(PART.6)　インフルエンザと新型コロナの感染防御でおさえておきたいこと. Expert Nurse 38(13): 36-42 , 2022
15. 三鴨廣繁、多屋馨子、石黒信久、岩田　敏、内田美保、岡田賢司、金井信一郎、豊川真弘、中野貴司、藤村　茂、山岸由佳: 一般社団法人日本環境感染学会ワクチン委員会　医療関係者のためのワクチンガイドライン(第3版)追補版　新型コロナワクチン. 日本環境感染学会誌 37(1): S1-S4, 2022
16. 長　和俊: 新生児の分娩損傷. 産科と婦人科89巻増刊: 59-62, 2022.03
17. 中村明枝：内分泌関連疾患の遺伝学と遺伝学的検査「内分泌疾患のジェネティクス」. 小児内分泌学　改訂第3版（日本小児内分泌学会［編］）：診断と治療社. 2022
18. 中村明枝：主要兆候からのアプローチ「高血糖」. 小児内分泌学　改訂第3版（日本小児内分泌学会［編］）：診断と治療社. 2022
19. 森川俊太郎：内分泌救急処置「低血糖」. 小児内分泌学　改訂第3版（日本小児内分泌学会［編］）：診断と治療社. 2022

令和3（2021）年度

2021年度研究費取得状況

論文・著書など

論文（欧文）

1. Nishimura A, Hirabayashi S, Hasegawa D, Yoshida K, Shiraishi Y, Ashiarai M, Hosoya Y, Fujiwara T, Harigae H, Miyano S, Ogawa S, Manabe A: Acquisition of monosomy 7 and a RUNX1 mutation in Pearson syndrome. Pediatr Blood Cancer 68: e28799, 2021
2. Ono R, Ashiarai M,Hirabayashi S, Mizuki K, Hosoya Y, Yoshihara H, Ohtake J, Mori S, Manabe A, Hasegawa D: Ruxolitinib for hematopoietic cell transplantation-associated hemophagocytic lymphohistiocytosis. Int J Hematol 113: 297-301, 2021
3. Nakagawa S, Kato M, Imamura T, Imai C, Koh K, Kawano Y, Shimomura Y, Watanabe A, Kikuta A, Saito A, Horibe K, Manabe A, Ohara A, Okamoto Y: In-hospital management might reduce induction deaths in pediatric patients with acute lymphoblastic leukemia: Results from a Japanese cohort. J Pediatr Hematol Oncol 43: 39-46, 2021
4. Hirabayashi S, Butler ER, Ohki K, Kiyokawa N, Bergmann AK, Möricke A, Boer JM, Cavé H, Cazzaniga G, Yeoh AEJ, Sanada M, Imamura T, Inaba H, Mullighan C, Loh ML, Norén-Nyström U, Pastorczak A, Shih LY, Zaliova M, Pui CH, Haas OA, Harrison CJ, Moorman AV, Manabe A: Clinical characteristics and outcomes of B-ALL with ZNF384 rearrangements: A retrospective analysis by the Ponte di Legno Childhood ALL Working Group. Leukemia 35(11): 3272-3277, 2021
5. Arakawa A,Ichikawa H, Kubo T, Motoi N, Kumamoto T, Nakajima M, Yonemori K, Noguchi E, Sunami K, Shiraishi K, Kakishima H, Yoshida H, Hishiki T, Kawakubo N, Kuroda T, Kiyokawa T, Yamada K, Yanaihara N, Takahashi K, Okamoto A, Hirabayashi S, Hasegawa D, Manabe A, Ono K, Matsuoka M, Arai Y, Togashi Y, Shibata T, Nishikawa H, Aoki K, Yamamoto N, Kohno T, Ogawa C: Vaginal transmission of cancer from mothers with cervical cancer to infants. N Engl J Med 384: 42-50, 2021
6. Tanaka Y, Yeoh AEJ, Moriyama T, Li CK, Kudo K, Arakawa Y, Buaboonnam J, Zhang H, Liu HC, Ariffin H, Chen Z, Kham S, Nishii R, Hasegawa D, Fujimura J, Keino D, Kondoh K, Sato A, Ueda T, Yamamoto M, Taneyama Y, Hino M, Takagi M, Ohara A, Ito E, Koh K, Hori H, Manabe A, Yang JJ, Kato M: An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 biallelic variants in children with acute lymphoblastic leukemia. Haematologica 106(7): 2026-2029, 2021
7. Kikuchi J, Ohhara Y, Takada K, Tanabe H, Hatanaka K, Amano T, Hatanaka K, Hatanaka Y, Mitsumura T, Kato M, Shibata Y, Yabe I, Endoh A, Komatsu Y, Matsuno Y, Sugiyama M, Manabe A, Sakurai A, Takahashi M, Naruse H, Torimoto Y, Akita HD, Kinoshita I: Clinical significance of comprehensive genomic profiling tests covered by public insurance in patients with advanced solid cancers in Hokkaido, Japan Jpn. J Clin Oncol hyaa277, 2021
8. Ishi Y, Shimizu A, Takakuwa E, Sugiyama M, Okamoto M, Motegi H, Hirabayashi S, Cho Y, Iguchi A, Manabe A, Nobusawa S, Tanaka S, Yamaguchi S: High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report. Pathol Int 71(5): 348-354, 2021
9. Okamoto M, Yamaguchi S, Ishi Y, Motegi H, Mori T, Hashimoto T, Terashita Y, Hirabayashi S, Sugiyama M, Iguchi A, Cho Y, Manabe A, Houkin K: Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor. Oncology.99(1): 23-31, 2021
10. Kawahara Y, Morimoto A, Inagaki J, Koh K, Noguchi M, Goto H, Yoshida N, Cho Y, Hori T, Hiwatari M, Kato K, Ogawa A, Hashii Y, Inoue M, Kato K, Atsuta Y, Kimura F, Kato M: Unrelated cord blood transplantation with myeloablative conditioning for pediatric acute lymphoblastic leukemia in remission: prognostic factors. Bone Marrow Transplant 56(2): 357-367, 2021
11. Ono R, Ueno H, Yoshida K, Takahashi S, Yoshihara H, Nozaki T, Suzuki K, Nakazawa A, Saiki R, Seki M, Takita J, Ogawa S, Manabe A, Hasegawa D: Clonal evidence for the development of neuroblastoma with extensive copy-neutral loss of heterozygosity arising in a mature teratoma. Cancer Sci 112: 2921-2927, 2021
12. Takachi T, Watanabe T, Miyamura T, Saito A, Deguchi T, Hori T, Yamada T, Ohmori S, Haba M, Aoki Y, Ishimaru S, Sasaki S, Ohshima J, Iguchi A, Takahashi Y, Hyakuna N, Manabe A, Horibe K, Ishii E, Koh K, Tomizawa D: Hematopoietic stem cell transplantation for infants with high-risk KMT2A gene rearranged acute lymphoblastic leukemia. Blood Adv 5: 3891-3899, 2021
13. Sugiyama M, Hirabayashi S, Ishi Y, Kikuchi J, Ishikura A, Motegi H, Ueda Y, Sawai S, Hara K, Terashita Y, Cho Y, Takakuwa E, Honda S, Yamaguchi S, Kinoshita I, Manabe A: Notable therapeutic response in a patient with systemic juvenile xanthogranuloma with KIF5B-ALK fusion. Pediatric Blood & Cancer 68(11), 2021
14. Hoshino Y, Sugiyama M, Hirata K, Honda S, Saito H, Manabe A, Kudo K: Extremely low 18F-fluorodeoxyglucose uptake in the brain of a patient with metastatic neuroblastoma and its recovery after chemotherapy: A case report. Acta Radiol Open 10, 2021
15. Yoshida M, Nakabayashi K, Yang W, Sato-Otsubo A, Tsujimoto SI, Ogata-Kawata H, Kawai T, Ishiwata K, Sakamoto M, Okamura K, Yoshida K, Shirai R, Osumi T, Moriyama T, Nishii R, Takahashi H, Kiyotani C, Shioda Y, Terashima K, Ishimaru S, Yuza Y, Takagi M, Arakawa Y, Kinoshita A, Hino M, Imamura T, Hasegawa D, Nakazawa Y, Okuya M, Kakuda H, Takasugi N, Inoue A, Ohki K, Yoshioka T, Ito S, Tomizawa D, Koh K, Matsumoto K, Sanada M, Kiyokawa N, Ohara A, Ogawa S, Manabe A, Niwa A, Hata K, Yang J, Kato M: NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia. Blood Adv 5: 5420-5428, 2021
16. Imai-Okazaki A, Matsunaga A, Yatsuka Y, Nitta KR, Kishita Y, Sugiura A, Sugiyama Y, Fushimi T, Shimura M, Ichimoto K, Tajika M, Ogawa-Tominaga M, Ebihara T, Matsuhashi T, Tsuruoka T, Kohda M, Hirata T, Harashima H, Nojiri S, Takeda A, Nakaya A, Kogaki S, Sakata Y, Ohtake A, Murayama K, Okazaki Y: Long-term prognosis and genetic background of cardiomyopathy in 223 pediatric mitochondrial disease patients. Int J Cardiol 341: 48-55, 2021
17. Gowda ST, Latson L, Sivakumar K, Hiremath G, Crystal M, Law M, Shahanavaz S, Asnes J, Veeram Reddy S, Kobayashi D, Alwi M, Ichida F, Hirono K, Tahara M, Takeda A, Minami T, Kutty S, Nugent AW, Forbes T, Prieto LR, Qureshi AM: Anatomical Classification and Posttreatment Remodeling Characteristics to Guide Management and Follow-Up of Neonates and Infants With Coronary Artery Fistula: A Multicenter Study From the Coronary Artery Fistula Registry. Circ Cardiovasc Interv 14(12): e009750, 2021
18. Chida-Nagai A, Yamazawa H, Tsujioka T, Taniguchi K, Sasaki O, Izumi G, Kato N, Takeda A: Left ventricular inflow obstruction due to a coronary arteriovenous fistula: a paediatric case report. CBMC Cardiovasc Disord 21(1): 389, 2021
19. Ito K, Chida-Nagai A, Sasaki O, Kato N, Umazume T, Kawaguchi S, Cho K, Izumi G, Yamazawa H, Takeda A: Total Anomalous Pulmonary Venous Connection with Lethal Pulmonary Venous Obstruction Managed by Multidisciplinary Cooperation. Case Rep Pediatr. 6619458, 2021
20. Maruo Y, Ueda Y, Murayama K, Takeda A: A case report of Leigh syndrome diagnosed by endomyocardial biopsy. European Heart Journal Case Reports 5(2), 2021
21. Saito H, Yazawa S, Shinozaki J, Murahara T, Shiraishi H, Matsuhashi M, Nagamine T: Appraisal of definition of baseline length for somatosensory evoked magnetic fields. J Neurosci Methods, 2021 May 2;359:109213.
22. Kada A, Tohyama J, Shiraishi H, Takahashi Y, Nakagawa E, Akiyama T, Saito AM, Inoue Y, Kato M: A Single-Arm Open-Label Clinical Trial on the Efficacy and Safety of Sirolimus for Epileptic Seizures Associated with Focal Cortical Dysplasia Type II: A Study Protocol. Kurume Med J 66(2): 115-120, 2021
23. Eguchi K, Shirai S, Matsushima M, Kano T, Ichikawa T, Yamazaki K, Hamauchi S, Sasamori T, Seki T, Kitagawa M, Shiraishi H, Houkin K, Sasaki H, Yabe I: Chronic deep brain stimulation reduces cortical β-γ phase amplitude-coupling in patients with Parkinson's disease. Parkinsonism Relat Disord 89: 148-150, 2021
24. Yoshitomi S, Hamano SI, Hayashi M, Sakuma H, Hirose S, Ishii A, Honda R, Ikeda A, Imai K, Jin K, Kada A, Kakita A, Kato M, Kawai K, Kawakami T, Kobayashi K, Matsuishi T, Matsuo T, Nabatame S, Okamoto N, Ito S, Okumura A, Saito A, Shiraishi H, Shirozu H, Saito T, Sugano H, Takahashi Y, Yamamoto H, Fukuyama T, Kuki I, Inoue Y: Current medico-psycho-social conditions of patients with West syndrome in Japan. Epileptic Disord 23(4): 579-589, 2021
25. Kinoshita A, Ohyama K, Tanimura S, Matsuda K, Kishino T, Negishi Y, Asahina N, Shiraishi H, Hosoki K, Tomiwa K, Ishihara N, Mishima H, Mori R, Nakashima M, Saitoh S, Yoshiura KI: Itpr1 regulates the formation of anterior eye segment tissues derived from neural crest cells. Development 148, 2021
26. Kuroda N, Kubota T, Horinouchi T, Ikegaya N, Kitazawa Y, Kodama S, Matsubara T, Nagino N, Neshige S, Soga T, Sone D, Takayama Y, Kuramochi I, Kanemoto K, Ikeda A, Terada K, Goji H, Ohara S, Hagiwara K, Kamada T, Iida K, Ishikawa N, Shiraishi H, Iwata O, Sugano H, Iimura Y, Higashi T, Hosoyama H, Hanaya R, Shimotake A, Kikuchi T, Yoshida T, Shigeto H, Yokoyama J, Mukaino T, Kato M, Sekimoto M, Mizobuchi M, Aburakawa Y, Iwasaki M, Nakagawa E, Iwata T, Tokumoto K, Nishida T, Takahashi Y, Kikuchi K, Matsuura R, Hamano S, Yamanouchi H, Watanabe S, Fujimoto A, Enoki H, Tomoto K, Watanabe M, Takubo Y, Fukuchi T, Nakamoto H, Kubota Y, Kunii N, Shirota Y, Ishikawa E, Nakasato N, Maehara T, Inaji M, Takagi S, Enokizono T, Masuda Y, Hayashi T: Risk factors for psychological distress in electroencephalography technicians during the COVID-19 pandemic: A national-level cross-sectional survey in Japan. Epilepsy Behav 125, 2021
27. Schoser B, Roberts M, Byrne BJ, Sitaraman S, Jiang H, Laforêt P, Toscano A, Castelli J, Díaz-Manera J, Goldman M, van der Ploeg AT, Bratkovic D, Kuchipudi S, Mozaffar T, Kishnani PS, Sebok A, Pestronk A, Dominovic-Kovacevic A, Khan A, Koritnik B, Tard C, Lindberg C, Quinn C, Eldridge C, Bodkin C, Reyes-Leiva D, Hughes D, Stefanescu E, Salort-Campana E, Butler E, Bouhour F, Kim G, Papadimas GK, Parenti G, Bartosik-Psujek H, Kushlaf H, Akihiro H, Lau H, Pedro H, Andersen H, Amartino H, Shiraishi H, Kobayashi H, Tarnev I, Vengoechea J, Avelar J, Shin JH, Cauci J, Alonso-Pérez J, Janszky J, Berthy J, Cornelia K, Gutschmidt K, Claeys K, Molnar MJ, Wencel M, Tarnopolsky M, Dimachkie M, Tchan M, Freimer M, Longo N, Vidal-Fernandez N, Musumeci O, Goker-Alpan O, Deegan P, Clemens PR, Roxburgh R, Henderson R, Hopkin R, Sacconi S, Fecarotta S, Attarian S, Wenninger S, Dearmey S, Hiwot T, Burrow T, Ruck T, Sawada T, Laszlo V, Löscher W, Chien YH: Safety and efficacy of cipaglucosidase alfa plus miglustat versus alglucosidase alfa plus placebo in late-onset Pompe disease (PROPEL): an international, randomised, double-blind, parallel-group, phase 3 trial. Lancet Neurol 20(12): 1027-1037, 2021
28. Maruo Y, Uetakea K, Egawa K, Shiraishi H: Selective eating in autism spectrum disorder leading to hair color change. Pediatr Neuro 120: 1-2, 2021
29. Egawa K, Saitoh S, Asahina N, Shiraishi H: Short-latency somatosensory-evoked potentials demonstrate cortical dysfunction in patients with Angelman syndrome. eNeurologicalSci 22, 2021
30. Egawa K, Nakakubo S, Kimura S, Goto T, Manabe A, Shiraishi H: Flurothyl-induced seizure paradigm revealed higher seizure susceptibility in middle-aged Angelman syndrome mouse model. Brain Dev 43(4): 515-520, 2021
31. Egawa K, Saitoh S, Asahina N, Shiraishi H: Variance in the pathophysiological impact of the hemizygosity of gamma-aminobutyric acid type A receptor subunit genes between Prader-Willi syndrome and Angelman syndrome. Brain Dev 43(4): 521-527, 2021
32. Yagyu K, Hashimoto R, Shimojo A, Iwata M, Sueda K, Seki A, Shiraishi H, Saito T: Development of a reading difficulty questionnaire for adolescents in Japanese. Brain Dev 43(9): 893-903, 2021
33. Daisho T, Kagami K, Yamazaki K, Ishiguro N, et al: Therapeutic drug monitoring-enabled long-term use of linezolid for the successful treatment of refractory pyogenic spondylodiscitis without development of thrombocytopenia: A case report. J Orthop Sci. Dec 15, 2021
34. Ishiguro N, Akutsu Y, Azuma K, et al: Evaluation of a Novel Immunochromatographic Assay Using Monoclonal Antibodies against the Matrix Protein of Human Metapneumovirus. Clin Lab: 67(10), 2021
35. Ishiguro N, Ito YM, Iwasaki S, et al: Three-day regimen of oseltamivir for post-exposure prophylaxis of influenza in hospital wards: a study protocol for a prospective, multi-center, single-arm trial. BMC Infect Dis 21(1): 887, 2021
36. Ishiguro N, Sato R, Kikuta H, et al: P1 gene of Mycoplasma pneumoniae isolated from 2016 to 2019 and relationship between genotyping and macrolide resistance in Hokkaido, Japan. J Med Microbiol 70(6), 2021
37. Kagami K, Ishiguro N, Yamada T, et al: Clinical outcomes of intervention for carbapenems and anti-methicillin-resistant Staphylococcus aureus antibiotics by an antimicrobial stewardship team. Am J Infect Control 49: 1493-1498, 2021
38. Kagami K, Ishiguro N, Yamada T, Niinuma Y, Iwasaki S, Taki K, Fukumoto T, Hayasaka K, Oyamada R, Watanabe T, Nishida M, Sugita J, Teshima T, Sugawara M, Takekuma Y: Efficacy and safety of colistin for the treatment of infections caused by multidrug-resistant gram-negative bacilli. J Infect Chemother 27(3): 473-479, 2021
39. Ishiguro N, Morioka I, Nakano T, et al: Clinical and virological outcomes with baloxavir compared with oseltamivir in pediatric patients aged 6 to < 12 years with influenza: an open-label, randomized, active-controlled trial protocol. BMC Infect Dis 21(1): 777, 2021
40. Ishiguro N, Sato R, Mori T, et al: Point-of-care molecular diagnosis of Mycoplasma pneumoniae including macrolide sensitivity using quenching probe polymerase chain reaction. PLoS One 16(10), 2021
41. Cho K, Kobayashi S, Araki A, Miyashita C, Itoh S, Saijo Y, Ito Y, Sengoku K, Baba T, Minakami H, Nakamura Y, Kishi R: Japan Environment and Children’s Study Group. Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children's Study. Pediatr Res 92(1): 291-298, 2021
42. Onda T, Akimoto T, Hayasaka I, Ikeda M, Furuse Y, Ando A, Nakamura Y, Honjo R, Manabe A, Furuta I, Cho K: Incidence of alveolar capillary dysplasia with misalignment of pulmonary veins in infants with unexplained severe pulmonary hypertension: The roles of clinical, pathological, and genetic testing. Early Hum Dev 155, 2021
43. Chida-Nagai A, Sato H, Sato I, Shiraishi M, Sasaki D, Izumi G, Yamazawa H, Cho K, Manabe A, Takeda A: Risk factors for hospitalisation due to respiratory syncytial virus infection in children receiving prophylactic palivizumab. Eur J Pediatr 181(2): 539-547, 2021
44. Ando A, Ohta H, Yoshimura Y, Nakagawa M, Asaka Y, Nakazawa T, Mitani Y, Oishi Y, Mizushima M, Adachi H, Kaneshi Y, Morioka K, Shimabukuro R, Hirata M, Ikeda T, Fukutomi R, Kobayashi K, Ozawa M, Takeshima M, Manabe A, Takahashi T, Mishima K, Kusakawa I, Yoda H, Kikuchi M, Cho K: Sleep maturation influences cognitive development of preterm toddlers. Sci Rep 11(1): 15921, 2021
45. Nishida D, Kawabe S, Iwata N, Cho K: ABCA3 deficiency dramatically improved by azithromycin administration. Pediatr Int 63(5): 602-604, 2021
46. Nagasaki K, Nakamura A, Yamauchi T, Kamasaki H, Hara Y, Kanno J, Koyama S, Ohtsu Y, Takahashi I, Suzuki S, Kashimada K, Tajima T: Investigation of TSH receptor blocking antibodies in childhood-onset atrophic autoimmune thyroiditis. Clin Pediatr Endocrinol 30(2): 79-84, 2021
47. Binder G, Nakamura A, Schweizer R, Ogata T, Fukami M, Nagasaki K: Long-term Effect of Aromatase Inhibition in Aromatase Excess Syndrome. J Clin Endocrinol Metab 106(5): 1491-1500, 2021
48. Poudel K, Kobayashi S, Miyashita C, Yamaguchi T, Tamura N, Ikeda-Araki A, Ait Bamai Y, Itoh S, Yamazaki K, Masuda H, Itoh M, Kishi R: Hypertensive Disorders during Pregnancy and Anthropometric Measurement of Children Up to 7 Years of Age: The Hokkaido Birth Cohort Study in Japan. Int J Environ Res Public Health 18(20), 2021
49. Miyashita C, Saijo Y, Ito Y, Ikeda-Araki A, Itoh S, Yamazaki K, Kobayashi S, Ait Bamai Y, Masuda H, Tamura N, Itoh M, Yamaguchi T, Yamazaki S, Kishi R and The Japan Environment and Children's Study Group: Association between the Concentrations of Metallic Elements in Maternal Blood during Pregnancy and Prevalence of Abdominal Congenital Malformations: The Japan Environment and Children’s Study. International Journal of Environmental Research and Public Health 18(19): 10103, 2021
50. Ishihara Y, Ohata Y, Takeyari S, Kitaoka T, Fujiwara M, Nakano Y, Yamamoto K, Yamada C, Yamamoto K, Michigami T, Mabe H, Yamaguchi T, Matsui K, Tamada I, Namba N, Yamamoto A, Etoh J, Kawaguchi A, Kosugi R, Ozono K, Kubota T: Genotype-phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling. Bon 153: 116135, 2021
51. Kishi R, Ikeda-Araki A, Miyashita C, Itoh S, Kobayashi S, Ait Bamai Y, Yamazaki K, Tamura N, Minatoya M, Ketema RM, Poudel K, Miura R, Masuda H, Itoh M, Yamaguchi T, Fukunaga H, Ito K, Goudarzi H; members of The Hokkaido Study on Environment and Children’s Health: Hokkaido birth cohort study on environment and children's health: cohort profile. Environ Health Prev Med 26(1): 59, 2021
52. Okamoto T, Nakamura A, Hayashi A, Yamaguchi T, Ogawa Y, Natsuga K, Yanagi K, Hotta K: Successful kidney transplantation in a patient with neonatal-onset ILNEB. Pediatr Transplant 25(5), 2021
53. Hayashi A, Takahashi T, Ueda Y, Sato Y, Okamoto T. Long-term clinical characteristics and renal prognosis of children with tubulointerstitial nephritis and uveitis syndrome. Pediatr Nephrol 36(8), 2021
54. Shimamura Y, Okamoto T, Abe K, Takuto M, Ogawa Y, Takizawa H. WAGR syndrome. Kidney Int 99(1), 2021
55. Urushihara M, Sato H, Shimizu A, Sugiyama H, Yokoyama H, Hataya H, Matsuoka K, Okamoto T, Ogino D, Miura K, Hamada R, Hibino S, Shima Y, Yamamura T, Kitamoto K, Ishihara M, Konomoto T, Hattori M; the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology. Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol 25(9), 2021
56. Tsuji Y, Yamamura T, Nagano C, Horinouchi T, Sakakibara N, Ishiko S, Aoto Y, Rossanti R, Okada E, Tanaka E, Tsugawa K, Okamoto T, Sawai T, Araki Y, Shima Y, Nakanishi K, Nagase H, Matsuo M, Iijima K, Nozu K. Systematic Review of Genotype-Phenotype Correlations in Frasier Syndrome. Kidney Int Rep 6(10), 2021
57. Fuke T, Nakamura A, Inoue T, Kawashima S, Hara KI, Matsubara K, Sano S, Yamazawa K, Fukami M, Ogata T, Kagami M: Role of Imprinting Disorders in Short Children Born SGA and Silver-Russell Syndrome Spectrum. J Clin Endocrinol Metab 106(3): 802-813, 2021
58. Shima H, Tokuhiro E, Okamoto S, Nagamori M, Ogata T, Narumi S, Nakamura A, Izumi Y, Jinno T, Suzuki E, Fukami M: SOX10 Mutation Screening for 117 Patients with Kallmann Syndrome. J Endocr Soc 5(7): bvab056, 2021
59. Higashimoto K, Watanabe H, Tanoue Y, Tonoki H, Tokutomi T, Hara S, Yatsuki H, Soejima H: Hypomethylation of a centromeric block of ICR1 is sufficient to cause Silver-Russell syndrome. J Med Genet 58(6): 422-425, 2021
60. Maruo Y, Egawa K, Tonoki H, Terae S, Ueda Y, Shiraishi H: Selective Eating in Autism Spectrum Disorder Leading to Kwashiorkor and Brain Edema. Pediatr Neurol 116: 55-56, 2021
61. Koga M, Suganuma A, Kikuchi T, Yoshimura Y, Shoji K, Kobayashi I, Takezaki S, Kato Y, Kimura M, Maruyama H; Research Group on Chemotherapy of Tropical Diseases, Japan: Primaquine plus clindamycin as a promising salvage therapy for Pneumocystis jirovecii pneumonia: A retrospective analysis in Japanese patients. J Infect Chemother 27(6): 924-928, 2021
62. Yamasaki Y, Kobayashi N, Akioka S, Yamazaki K, Takezaki S, Nakaseko H, Ohara A, Nishimura K, Nishida Y, Sato S, Kishi T, Hashimoto M, Mori M, Okazaki Y, Kuwana M, Ohta A: Clinical impact of myositis-specific autoantibodies on long-term prognosis of juvenile idiopathic inflammatory myopathies: multicentre study. Rheumatology (Oxford) 60(10): 4821-4831, 2021
63. Yamazaki K, Ohta A, Akioka S, Yamasaki Y, Ohara A, Nakaseko H, Nishimura K, Kobayashi N, Nishida Y, Sato S, Takezaki S, Kishi T, Hashimoto M, Kobayashi I, Mori M; group of Juvenile Idiopathic Inflammatory Myopathies in the Research Team for Pediatric Rheumatic Disease, The Research Program for Intractable Disease of the Ministry of Health, Labor and Welfare: External validation of the EULAR/ACR idiopathic inflammatory myopathies classification criteria with a Japanese paediatric cohort. Rheumatology (Oxford) 60(2): 802-808, 2021
64. Sato T, Takezaki S, Goto T, Ishikawa S, Oura K, Takahata A, Shiraishi H, Maruo Y, Sato N, Suganuma T, Mikawa M: Atypical Familial Mediterranean Fever in a Japanese Boy with Heterozygous MEFV p.Ser503Cys Exon 5 Variant. Case Rep Pediatr: 1-6, 2021

論文（邦文）

1. 永井礼子: 肺高血圧症における基礎研究の最近の話題：分子遺伝学的背景を中心に. 日本小児循環器学会雑誌 37(1): 2-9, 2021
2. 武田充人: ミトコンドリア心筋症. 循環器診療コンプリート「心筋症」秀潤社, 2021.3
3. 武田充人: 小児遺伝子疾患事典　PKP2（関連疾患：不整脈原性右室心筋症）. 小児科診療　特大号84(11), 2021
4. 武田充人、村山　圭、岡崎康司、John M Basgen 他: 【Best Articles of the Year】ミトコンドリア心筋症における特殊診断のための病理学的研究. Hokkaido J Med Sci 96(2), 2021
5. 永井礼子: 小児遺伝子疾患事典　BMPR2（関連疾患：遺伝性肺高血圧症）. 小児科診療　特大号84(22), 2021
6. 永井礼子: 先天性心疾患に伴う肺高血圧症と遺伝学的特性. Pulmonary Hypertension Update 7(2): 38-42, 2021
7. 白石秀明: 学童期のてんかん、発作性疾患. 小児科診療84: 37-43, 2021
8. 白石秀明: 結節性硬化症に伴うてんかんに対するエベロリムスの有効性. 小児科62: 1351-1356, 2021
9. 白石秀明: 学童期の神経疾患のファーストタッチから専門診療へ. 小児科診療: 37-43, 診断と治療社, 東京, 2021
10. 白石秀明: 小児科医からのTransition. 今日の精神科治療ハンドブック・精神治療学: 288-289, 星和書店, 東京, 2021
11. 白石秀明: 特集　てんかん　徐波睡眠時持続性棘徐波を示すてんかん脳症（EECSWS）. 小児内科: 1701-1704, 東京医学社, 東京, 2021
12. 白石秀明: 小児脳波超速ラーニング. 全111頁, 南山堂, 東京, 2021
13. 林　麻子、高橋俊行、上田泰弘、佐藤泰征、岡本孝之: 小児における尿細管間質性腎炎ぶどう膜炎症候群の長期的な臨床的特徴と腎予後についての後方視的検討. Hokkaido J Med Sci 96(1): 14 Best Articles of the year, 2021
14. 石黒信久: NICUにおける薬剤耐性菌の制御. 日本新生児成育医学会雑誌 33(3): 518-524, 2021
15. 長　和俊: 呼気終末陽圧の効果. 周産期医学 51(7): 1007-1009, 2021
16. 太田英伸、安達裕行、有光威志、兼次洋介、長　和俊、齋藤朋子、下風朋章、豊島勝昭: NICU空間を光・音で切り分ける　神奈川こどもでの試みも含めて. 小児外科 53(7): 700-703, 2021
17. 長　和俊: 呼吸窮迫症候群. 周産期医学51巻増刊: 589-591, 2021.12
18. 長　和俊: 気胸、エアリーク. 小児内科 53巻増刊: 104-106, 2021.12
19. 外木秀文: ダウン症候群の移行支援ガイド. 札医通信 648: 14-16 , 2021

過去の業績

• 令和2（2020）年度
• 平成31（2019）年度
• 平成30（2018）年度
• 平成29（2017）年度
• 平成28（2016）年度
• 平成27（2015）年度
• 平成26（2014）年度
• 平成25（2013）年度
• 平成24（2012）年度
• 平成23（2011）年度
• 平成22（2010）年度
• 平成21（2009）年度
• 平成20（2008）年度
• 平成19（2007）年度
• 平成18（2006）年度
• 平成17（2005）年度
• 平成16（2004）年度